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47 Cards in this Set

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Lipids & Lipoproteins are organic substances ________ in water.
Insoluble
Lipids & Lipoproteins are organic substances __________ in organic solvents.
Soluble
The four human plasma lipids are:
Cholesterol
Triglycerides
Phospholipids
Non-Esterified fatty acids
Lipids combine with protein in the liver to form ______.
Lipoprotein.

Transport
Low density lipoproteins are _____%.
60-70%
High density lipoproteins are _____%.
20-35%
Very Low lipoproteins are _____%.
5-12%
A protein portion of the lipoproteins:
Apolipoprotein
Apolipoprotein A is the major protein of _______.
HDL
Apolipoprotein B is the major protein of _______.
LDL
Apolipoprotein C is the major protein of _______.
VLDL and chylomicrons

minor protein of HDL & LDL
LDL brings cholesterol ____ the cells.
INTO
HDL brings cholesterol ___ of the cells.
OUT
The primary form of lipid storage?
Triglycerides
Chylomicrons and VLDL transport ________.
Triglycerides
Chylomicrons are considered to be __________
exogenous dietary triglycerides
VLDL are considered to be __________
endogenous triglycerides
Precursor to steroid hormones?
Cholesterol
LDL transports _______ to cells.
Cholesterol
HDL transport cholesterol ____ of cells.
OUT
Tryglicerides are transported in the form of
lipoproteins
The four classes of lipoproteins are:
chylomicrons
LDL
HDL
VLDL
The lipid triglyceride is transported by ______ and ____.
Chylomicrons and VLDL
The lipid cholesterol is transported by ____ and ____.
HDL and LDL.
The lipoprotein chylomicrons are transported by lipids of ______ __________.
exogenous (dietary) triglycerides
The lipoprotein VLDL are transported by lipids of ______ ______.
endogenous triglycerides
The lipoprotein HDL are transported by lipids of _________ out of cell (heart).
cholesterol
The lipoprotein LDL are transported by lipids of _________ into cell (heart).
cholesterol
A _____ hour fast is required for lipid testing.
12 hour fast
Non-fasting may cause a turbid layer of ______ on top following refrigeration.
chylomicrons
(abnormal finding in fasting specimens)
Non fasting may cause an ____ of triglycerides.
Increase
Cholesterol is enzymatically measured by ______ _____.
Cholesterol oxidase
Triglycerides is enzymatically measured by liberating _____ by ______
liberation of glycerol by lipase
False elevation of triglycerides can be due to ____ contamination.
Glycerol contamination from stoppers of tubes or ingestion of glyerol-coated medication
The measurement of HDLc without pretreatment is considered a _____ assay.
Direct/Homogenous Assay
The measurement of HDLc with an indirect method removes the chlomicrons, VLDL, and LDL by __________.
preciptation

Analyze supernatant for HDLc
The reference method is ___________.
Ultracentrifugation

Separates lipoproteins by their rates of flotation
The calculation of LDLc and VLDLc is the ________ method
Friedewald method
The Friedewald method cannot be used when ____________.
Triglycerides >400mg/dL
(Total chol)-(HDLc)-(TG/5)=
LDLc

Total cholesterol-HDLc-VLDL=LDLc
(plasma TG in mg/dL)/5=
VLDLc
The total cholesterol goal from a lipid screening should be _______.
<200mg/dL
The HDLc goal from a lipid screening should be ______.
>35mg/dL
The triglyceride goal from a lipid screening should be _______.
<150mg/dL
If levels of lipid screening are outside goals, follow-up testing should include ________ and _________.
A 12 hour fasting sample and a lipoprotein analysis
Treatment is based on the ____ results from lipoprotein analysis and other risk factors.
LDLc
Risk factors for heart disease include:
family history, age, smoking, diabetes, hypertension