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26 Cards in this Set
- Front
- Back
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T or F: hodgkin's lymphoma is more common than non-hodgkins.
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false; non-hodgkins is more common
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what is the most common age group affected by NHL?
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> 50 years old
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what is the most common age group affect by hodkin's lymphoma?
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bimodal distribution with peaks at 20 and 65
the majority of the cases however are of young adults |
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what are the four infectious agents associated with NHL and what specific type of NHL are they associated with?
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- H. pylori = gastric MALT NHL
- EBV = Burkitt's lymphoma - Hepatitis C = Indolent NHL - HTLV 1 = Adult T cell leukemia/lymphoma |
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what order should you perform lab studies in when trying to diagnose lymphoma?
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- CBC
- Liver function test - renal failure test - LDH - B2 microglobin - Albumin - Uric acid - Alkaline phosphatase |
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T or F: when doing a lymph node biopsy for lymphoma it is ok to just do an aspirate.
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false, you need to biopsy the entire node
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T or F: when doing a bone marrow biopsy for lymphoma you need to biopsy both hips.
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true
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Ann Arbor Stage I for NHL
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involvement of a single lymph node region
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Ann Arbor Stage II for NHL
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more than 2 lymph node regions on the same side of the diaphragm
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Ann Arbor Stage III for NHL
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lymph nodes on both sides of the diaphragm including the spleen
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Ann Arbor Stage IV for NHL
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multifocal involvement of more than 1 extralymphatic site
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what are B symptoms?
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constitutional symptoms that may or may not be seen in NHL
specifically these include temp > 38 C, night sweats, and > 10% weight loss |
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list the factors in the IPI score.
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- age
- LDH - performance status - Extranodal involvement - Stage |
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what is the IPI score used for?
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to determine a prognosis for diffuse large B cell lymphoma
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what is CHOP?
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the standard chemotherapy used when treating diffuse large B cell lymphoma. it includes:
- Cytoxan (cyclophosphamide) - Hydroxydaunomycin - Oncovin (vincristine) - prednisone |
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what is the major side effect of Rituximab?
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it may cause reactivation of Hep B virus
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what are the low grade NHLs?
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follicular lymphoma
small lymphocytic lymphoma |
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what age group is usually affected by low grade NHLs?
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patients are usually > 65 years old
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what is the prognosis for low grade NHLs?
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these are incurable and often transform into aggressive histology with a median survival of less than 1 year
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what are the high grade lymphomas?
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- large immunoblastic
- lymphoblastic - Burkitts - Non-Burkitts - PTLD - HIV associated |
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what is tumor lysis syndrome?
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when massive amounts of tumor cells lyse (due to treatment) they release potassium and uric acid. this can lead to renal failure and hypocalcemia
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what is the cause of MALT lymphoma of the gastric mucosa?
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helicobacter pylori infection
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how do you treat MALT lymphoma of the gastric mucosa?
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triple therapy
- PPI - Amoxicillin - Clarithromycin eradication of H. pylori usually induces remission |
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what are Reed-Sternberg cells diagnostic for?
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Hodgkin's lymphoma
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what are the prognostic factors for Hodgkin's lymphoma?
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- age
-gender - stage - albumin - hemoglobin - WBC - lymphocytes |
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how do we treat Hodgkin's lymphoma?
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ABVD
- adriamycin - bleomycin - vinblastine - decarbazine |
