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16 Cards in this Set
- Front
- Back
Prone to avascular necrosis in this disease
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Sickle-cell disease
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-Caused by burns, infections, cancer, drugs and many chronic concurrent illnesses such as seen in patient in the ICU
-Elevation of lactate dehydrogenase, bilirubin, PT and PTT -Decrease fibrinogen and platelets |
DIC
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FAT RN
-TTP -thrombotic thrombocytopenic purpura |
Fever
Anemia Thrombocytopenia Renal problems Neurological symptoms |
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E. coli 0571 infection causes hemolysis in the kidneys ("burns" kidney)) causing renal failure
Platelet are activated and are not broken up Damage passing RBCs - hemolysis, especially in kidneys Effects younger patients Tx focus on E. coli |
HUS - hemolytic uremic syndrome
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Caused by larger objects in vasculature that damage RBC
Body thinks its bleeding, large consumption of vWF, as in TTP, unable to clot in other areas do to decrease. Secondary bleeding |
Macroangiopathic hemolysis
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Fever
Anemia Thromboctopenia Renal problems Neurological symptoms |
Thrombotic thrombopenic purpura
(TTP) FAT RN |
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Large consumption of vWF, as in TTP, unable to clot in other areas do to decrease of vWf.
ADAMTS 13 involved |
Thrombotic thrombopenic purpura
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Three methods of Drugs damaging cells
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1. Direct hemolysis/oxidation
2. Preformed Abs against certain molecules -penicillin attaches to RBC - abs attach to penicillin - RBC removed by spleen 3. Being marked by complement (hapten response) -Drug attaches to RBC - comp activated against foreign surface molecule - RBC phagocytized or removed by spleen |
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-Increased lactate dehydrogenase, bilirubin, and K+
-Decreased Calcium and haptoglobin -Renal problems |
Markers for hemolysis
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In an autoimmune response, cells are taken up in the spleen and destroyed due to
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IgG
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Intravascular hemolysis occurs in response to :
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Compliment
autoimmune |
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Which test should be done if hemolytic anemia is suspected?
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Direct Coombs
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What conditions will cause autoimmunity in the patient?
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Lupus, HIV, drugs, idiopathic
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What type of Bone marrow failure anemia?
-Fanconi anemia, Down syndrome |
Inherited
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What type of Bone marrow failure anemia?
Marrow stops producing blood for unknown reason. -Tx - immunosuppress -Don't use relatives for transfusion, save them for stem cell transplant |
Aplastic
-lymphocytes fine - produced in thymus/spleen -appears to be immune mediated -high level immunosuppression required |
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What type of Bone marrow failure anemia?
Marrow becomes scar, patient shifts to spleen (splenomegaly) and patient will die when no longer can compensate. -due to radiation, chemo, drugs, occupational exposure (benzene, insecticides) parvovirus B19 |
Fibrosis
-condition of elderly, should not transplant them -irrecoverable marrow damage |