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13 Cards in this Set
- Front
- Back
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1. What is bioavailability?
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a. Fraction of a drug that reaches the systemic circulation following administration by any route
b. Must be between 0 and 1 |
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2. What is volume of distribution?
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a. How much of the drug stays in the plasma versus how much is distributed throughout the body
b. Higher VOD=less stays in the blood |
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3. How are most drugs excreted?
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a. In the urine
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4. What is clearance?
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a. How much of a drug is excreted
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5. What is characteristic of zero-order kinetics?
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a. The amount of a drug that is excreted does not change with changing concentration
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6. What is characteristic of first-order kinetics?
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a. Fraction of the drug that is excreted is constant
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7. What is half-life?
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a. Amount of time required for the plasma drug concentration to decrease by one-half
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8. How many half-lives are required for a drug to be out of the system?
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a. 5
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9. How do you calculate adjusted body weight?
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a. ABW=IBW+.4(TBW-IBW)
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10. How do you calculate creatinine clearance?
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a. [(140-age)*IBW]/(72*serum creatinine)
b. Multiply by .85 if a woman |
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11. How is vancomycin dosed?
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a. Renally
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12. What is steady state?
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a. The amount of drug going in is the same as the amount going out
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13. When can you usually get a trough measurement?
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a. Prior to 4th dose
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