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36 Cards in this Set

  • Front
  • Back
what is the most likely inciting incidence of RA?
activation of the T cell by a putative antigen in a genetically susceptible patient
what antibody seems to be predictive of RA?
Anti-CCP
what are the 2 earliest components of the inflammatory cascade in RA?
TNF-alpha
IL-1
who should be tested for RA?
patients who have at least one joint with definitive clincal synovitis
what predicts that patients will always be seropositive for RF?
rheumatoid nodules
what happens to the skin in RA?
hyperpigmentation even after symtoms improve
in what disease will you see boutonniere or swan-neck deformity?
RA
what is an auto-immune exocrinopathy?
sjogren's syndrome
what 3 main glands are attacked in sjogren's syndrome?
lacrimal glands
vaginal mucosal glands
salivary glands
what syndrome is associated with leukopenia, specifically the granulocytes and thus leads to recurrent infections?
Felty's syndrome
what antibodies found in primary sjogren's syndrome will indicate that it is not due to RA?
SS-A and SS-B
what extra-articular manifestations of RA stretch the ligaments of c-spine?
myelopathy
when must you protect the spine in myelopathy?
if the distance between the posterior border of anterior arch of C1 and anterior border of the dens is greater than 4mm in flexion
how can you differentiate between rheumatoid lung and lung cancer?
if the patient is RF-negative, it will probably be cancer
what extra-articular manifestation of RA is associated with a very poor prognosis?
inflammatory eye disease
what are 6 lab findings of RA?
RH+
anti-CCP antibody
elevated ESR or CRP
anemia
thrombocytosis
ANA+
what are 2 main pharm treatments of RA?
DMARDs and biologics
what are the 4 remission criteria for RA?
AM stiffness <15minutes
no fatigue
no joint pain or tenderness on ROM
no STS in joints or tendon sheaths
3 classification criteria for pediatric rheumatic disease
AOS <17
arthritis in one or more joints
duration of disease > 6 weeks
what are 3 types of onset of pediatric rheumatic disease?
polyarthritis
pauciarthritis
systemic disease
in which pediatric rheumatic disease will you have one or more joints involved and extra-articular features lasting longer than 6 weeks?
stills disease
in which pediatric rheumatic disease will you have a macular, salmon colored rash?
stills disease
in which pediatric rheumatic disease is the age of onset usually <5 and F=M but F>M when older than 5?
stills disease
what disease will have the following lab values?
high ESR
Anemia
leukocytosis
thrombocytosis
IgM RF negative
ANA negative
stills disease
what is the prognosis for stills?
the younger the patient, the greater the risk of poor health, both somatic and joints
what is pauciarticular arthritis?
less than 5 joints involved
what is the population affected by pauciarthritis?
>9 yo
M>F
in which pediatric rheumatic disease will you have enthesopathies, acute irisits, and come sacroiliac pain?
pauciarticular
what disease will have non-specific lab findings except for HLA-B27+?
pauciarticular
what pediatric rheumatic disease will affect mostly 8 year olds?
psoriatic
what pediatric rheumatic disease will present with swollen digits and symmetric peripheral joints
psoriatic
what pediatric rheumatic disease is often associated with tenosynovitis and nail changes?
psoriatic
what is the prognosis of pediatric psoriatic arthritis?
generally good
what will the the lab findings with poliarticular atrhtitis?
may be RF + or - but ANA will be +
what pediatric rheumatic disease will affect any age with multiple joint involvement?
poliarticular
what are two key things that distinguish growing pains fro arthritis?
growing pains will be localized to the thighs, calves, and shins (not joints)
growing pains will be most frequent late in the day or night (not morning)