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36 Cards in this Set
- Front
- Back
what is the most likely inciting incidence of RA?
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activation of the T cell by a putative antigen in a genetically susceptible patient
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what antibody seems to be predictive of RA?
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Anti-CCP
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what are the 2 earliest components of the inflammatory cascade in RA?
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TNF-alpha
IL-1 |
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who should be tested for RA?
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patients who have at least one joint with definitive clincal synovitis
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what predicts that patients will always be seropositive for RF?
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rheumatoid nodules
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what happens to the skin in RA?
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hyperpigmentation even after symtoms improve
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in what disease will you see boutonniere or swan-neck deformity?
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RA
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what is an auto-immune exocrinopathy?
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sjogren's syndrome
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what 3 main glands are attacked in sjogren's syndrome?
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lacrimal glands
vaginal mucosal glands salivary glands |
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what syndrome is associated with leukopenia, specifically the granulocytes and thus leads to recurrent infections?
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Felty's syndrome
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what antibodies found in primary sjogren's syndrome will indicate that it is not due to RA?
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SS-A and SS-B
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what extra-articular manifestations of RA stretch the ligaments of c-spine?
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myelopathy
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when must you protect the spine in myelopathy?
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if the distance between the posterior border of anterior arch of C1 and anterior border of the dens is greater than 4mm in flexion
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how can you differentiate between rheumatoid lung and lung cancer?
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if the patient is RF-negative, it will probably be cancer
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what extra-articular manifestation of RA is associated with a very poor prognosis?
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inflammatory eye disease
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what are 6 lab findings of RA?
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RH+
anti-CCP antibody elevated ESR or CRP anemia thrombocytosis ANA+ |
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what are 2 main pharm treatments of RA?
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DMARDs and biologics
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what are the 4 remission criteria for RA?
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AM stiffness <15minutes
no fatigue no joint pain or tenderness on ROM no STS in joints or tendon sheaths |
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3 classification criteria for pediatric rheumatic disease
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AOS <17
arthritis in one or more joints duration of disease > 6 weeks |
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what are 3 types of onset of pediatric rheumatic disease?
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polyarthritis
pauciarthritis systemic disease |
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in which pediatric rheumatic disease will you have one or more joints involved and extra-articular features lasting longer than 6 weeks?
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stills disease
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in which pediatric rheumatic disease will you have a macular, salmon colored rash?
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stills disease
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in which pediatric rheumatic disease is the age of onset usually <5 and F=M but F>M when older than 5?
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stills disease
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what disease will have the following lab values?
high ESR Anemia leukocytosis thrombocytosis IgM RF negative ANA negative |
stills disease
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what is the prognosis for stills?
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the younger the patient, the greater the risk of poor health, both somatic and joints
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what is pauciarticular arthritis?
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less than 5 joints involved
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what is the population affected by pauciarthritis?
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>9 yo
M>F |
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in which pediatric rheumatic disease will you have enthesopathies, acute irisits, and come sacroiliac pain?
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pauciarticular
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what disease will have non-specific lab findings except for HLA-B27+?
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pauciarticular
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what pediatric rheumatic disease will affect mostly 8 year olds?
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psoriatic
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what pediatric rheumatic disease will present with swollen digits and symmetric peripheral joints
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psoriatic
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what pediatric rheumatic disease is often associated with tenosynovitis and nail changes?
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psoriatic
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what is the prognosis of pediatric psoriatic arthritis?
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generally good
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what will the the lab findings with poliarticular atrhtitis?
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may be RF + or - but ANA will be +
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what pediatric rheumatic disease will affect any age with multiple joint involvement?
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poliarticular
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what are two key things that distinguish growing pains fro arthritis?
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growing pains will be localized to the thighs, calves, and shins (not joints)
growing pains will be most frequent late in the day or night (not morning) |