Clerkship - Neuro - Movement Disorders (Blueprints)

Front 1

4 Cardinal Features of Idiopathic Parkinsons

Back 1

tremor, rigidity, bradykinesia, postural instability

Front 2

5 Parkinsonian Syndromes

Back 2

Progressive Supranuclear Palsy

Corticobasal Ganglionic Degeneration

Diffuse Lewy Body Disease

Vascular Parkinsonism

Multiple Systems Atrophy

Front 3

Supranuclear opthalmoplegia, with limitation of vertical more than horizontal gaze; axial rigidity and neck extension early falls as a consequence of imparied postural reflexes, neck extension, and inability to look down

Back 3

Progessive Supranuclear Palsy

Front 4

Apraxia, cortical sensory impairment and alien-limb phenomenon; severe unilateral rigidity; stimulus-sensative myoclonus

Back 4

Corticobasal Ganglionic Degeneration

Front 5

Early dementia
Prominant visual hallucinations
Extreme sensativity to extrapyramidal side-effects of antidopaminergic neuroleptic drugs

Back 5

Diffuse Lewy Body Disease

Front 6

"Lower-half" parkinsonism with rigidity in legs and marked gait impairment; other evidence of diffuse vascular disease (corticospinal tract dysfunction, pseudobulbar palsy)

Back 6

Vascular Parkinsonism

Front 7

Early and prominent features of autonomic dysfunction
Evidence of corticospinal tract dysfunction
Cerebellar signs
Stimulus-sensative myoclonus
Vocal cord paresis

Back 7

Multiple systems atrophy

Front 8

The tremor in Idiopathic Parkinsons is fast/slow?
and more prominant when limb is at rest/in motion?

Back 8

slow

worst when limb is at rest

Front 9

Dementia or delerium is seen in Parkinsons?

Back 9

Dementia in 1/3 of pts

Front 10

What is the name of L-Dopa + Carbidopa?

Back 10

Sinemet. Carbidopa inhibits peripheral decarboxylase (preventing dopamine formation outside the CNS)

Front 11

What is selegeline?

Back 11

monoamine oxidase B inhibitor

Front 12

Muscular rigidity, fever, autonomic lability, altered level of consciousness, elevated creatine kinase level, leukocytosis

Back 12

Neuroleptic Malignant Syndrome (NMS) <-- drugs with dopamine receptor-blocking activity

Front 13

Neuroleptic Malignant Syndrome (NMS)

Back 13

Muscular rigidity, fever, autonomic lability, altered level of consciousness, elevated creatine kinase level, leukocytosis <-- drugs with dopamine receptor-blocking activity (neuroleptics)

Front 14

What is Akathisia?

Back 14

an dysphoric state characterized by the subjective desire to be in constant motion <-- drugs with dopamine receptor-blocking activity

Anticholinergics and Beta blockers can be used to treat this

Front 15

symptoms of Tardive Dyskinesia

Back 15

Orolinguomasticatory dyskenisia <-- drugs with dopamine receptor-blocking activity (neuroleptics)

Sx: chewing movements, lip smacking, rolling of the tongue inside the cheek.

Tx: discontinue affecting agent. Dopamine depleting agents (reserpine, tetrabenzine) may help

Front 16

Name 2 anticholinergics for Parkinsons Tx

Back 16

Trihexyphenidyl

Benztropin (Michael J Fox driving a Benz)

Side Effects: Dry mouth, constipation, urinary retention, confusion, hallucination, narrow-angle glaucoma

Front 17

Name an NMDA antagonist for Parkinsons Tx

Back 17

Amantadine

Front 18

Name 4 Dopamine agonists for Parkinsons Tx

Back 18

Bromocriptine

Pergolide

Pramipexole

Ripinirole

Side effects: Nausea, orthostatic hypotension, psychosis, hallucinations, dyskinesia (Same as Levodopa/Carbidopa)

Front 19

Name 2 COMT inhibitors for Parkinsons Tx

Back 19

Tolcapone

Entacapone

similar side effects to levodopa/carbidopa and dopamine agonists.
Nausea, orthostatic hypotension, confusion, dyskinesia

Front 20

Mechanism of levodopa/carbidopa

Back 20

Dopamine precursor/dopa decarboxylase inhibitor

Side effects: anorexia, nausea, psychosis, hallucinations, orthostatic hypotension, dyskinesia

Front 21

chonic axial muscle rigidity and stiffness and painful muscle spasms

Back 21

Stiff-person syndrome

Front 22

What antibody is associated with Stiff-person syndrome?

Back 22

Anti-GAD antibodies


"chonic axial muscle rigidity and stiffness and painful muscle spasms"

Front 23

Causes of resting tremor

Back 23

Parkinson's Disease

Parkinsonian Syndromes

Front 24

Causes of postural tremor

Back 24

(emerges during sustained maintenance of posture)

Essential Tremor
Physiologic tremor
Drugs (eg. theophylline, beta-agonists)
Alcohol

Front 25

Causes of action tremor

Back 25

Cerebellum and cerebellar outflow tract dysfunction (e.g. infarction, multiple sclerosis, tumor, Wilson's disease, drugs)

Front 26

what is intention tremor?

Back 26

a tremor that increases as the target is approached