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15 Cards in this Set

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What is the MOA of Clindamycin (Cleocin) ?
BACTERIOSTATIC inhibitor of protein synthesis
The uses of Cleocin are limited because of what major side effect ?
AAPMC - antibiotic associated psuedomembranous colitis
What is the spectrum of Cleocin ?
Active against most anaerobic gram negative and gram positive.
-Gram negative AEROBES are resistant
Bacteroides, fusobacterium, clostridium
What is Cleocin generally used for ?
Used to be used as an alternative to penicillin but not so much anymore due to the colitis
-used today primarily for anaerobic infections OUTSIDE the CNS
-is the DOC for abdominal and pelvic infections caused by B. fragilis
-diabetic foot ulcers, necrotizing fascitis
acne
-bacterial vaginosis
-alternative therapy for AIDS patients to treat pnuemocystic carnii
-MRSA
Discuss the distribution of Cleocin in the tissues ...
widely distributed to bone and body tissues; poor perfusion to CNS
Dose dosage need to be reduce for renal or hepatic dysfunction ?
NO....but the drug *can* accumulate to toxic levels in combined renal/hepatic dysfunction. Reduce the dose or use another drug if this is the case.
What are the signs and symptoms of AAPMC ?
profuse, watery diarrhea (10-20 stools per day); abdominal pain, fever, leukocytosis. Stools may contain mucus or blood.
When do symptoms of AAPMC usually begin ?
within the first week of therapy OR up to 4-6 weeks after completion
What should you do and what should you prescribe for the patient who has signs and symptoms of AAPMC ?
1. STOP Cleocin
2. Give oral Vancomycin or Metronidazole
3. Vigorous fluid replacement therapy
4. Do not use drugs that slow motility like opiods and anticholinergics !
IV administration should be on or off the pump ?
Should be ON the pump and given slowly.
Pediatric concerns ?
OK for kids > 1 month
What pregnancy category is it ?
B
If you prescribe Cleocin in vaginal cream form, what else should you tell your patients ?
The cream *may* weaken the diaphragm and condoms, so backup birth control is a good idea.
How does Cleocin work ?
BACTERIOSTATIC ! inhibits protein wall synthesis
What is the name of the form of Cleocin that is given in cream form for vaginosis ?
Clindesse