Classic Labs/findings From Usmle First Aid

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Anticentromere antibodies

Back 1

Scleroderma (CREST)

Front 2

Antidesmoglein (epithelial) antibodies

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Pemphigus vulgaris (blistering)

Front 3

Anti-GBM antibodies

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Goodpasture's

Front 4

Antihistone antibodies

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Drug-induce SLE

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Anti-IgG antibodies

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Rheumatoid arthritis

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Antimitochondrial antibodies (AMAs)

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Primary biliary cirrhosis (cholestasis, portal HTN)

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Antineutrophil cytoplasmic antibodies (ANCAs)

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Vasculitis (Wegener's, microscopic polyangiitis)

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ANA's and anti-dsDNA

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SLE

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Antiplatelet antibodies

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Idiopathic thrombocytopenic purpura

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Anti-topoisomerase antibodies

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Diffuse systemic scleroderma

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Anti-transglutaminase/antigliadin antibodies

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Celiac disease

Front 12

Name and cause of Azurophilic granular needles in luekemic blasts

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Auer rods (AML, promyelocytic type)

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"Bamboo spine" on x-ray

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Ankylosing spondylitis

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HLA type in ankylosing spondylitis

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HLA-B27

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Name and cause of basophilic nuclear remnants in RBC's

Back 15

Howell-Jolly bodies (removed/nonfuncitonal spleen)

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Basophilic stippling of RBC's

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Lead poisoning or sideroblastic anemia

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Bloody tap on lumbar puncture

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Subarachnoid hemorrhage

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"Boot shaped" heart

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Right ventricular hypertrophy and/or tetralogy

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Branching gram-positive rods with sulfur granules

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Actinomyces israelii

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Bronchogenic apical lung tumor

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Pancoast's tumor

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Lung tumor causing Horner's

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Pancoast's tumor

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Reason for color and two dx's for "brown" tumor of bone

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Hemorrhage (hemosiderin) in osteolytic cysts. Can be hyperparathyroidism or osteitis fibrosa cystica (von Rechlinghausen's disease)

Front 23

Cardiomegaly + apical atrophy

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Chagas' disease (Trypanosoma cruzi)

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Cellular crescents in Bowman's capsure

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Rapidly progressive crescentic glomerulonephritis

Front 25

Chocolate cyst of ovary. Likely unilateral or B/L?

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Endometriosis - B/L

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Name and dx for circular grouping of dark tumor cells surrounding pale neurofibrils

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Homer Wright rosesttes - neuro/medullo/retinoblastoma

Front 27

Likely disease underlying pseudomonas in lungs

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Cystic Fibrosis

Front 28

Degeneration of dorsal column nerves

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Tabes dorsalis (tertiary syphylis)

Front 29

Depigmentation of neurons in substantia nigra

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Parkinson's

Front 30

Desquamated epithelium casts in sputum

Back 30

Curschmann's spiral - bronchial asthma

Front 31

Disarrayed granulosa cells in eosinophilic fluid

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Call/Exner bodies - granulosa-theca cell tumor

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Enlarged cells with intranuclear inclusion bodies

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Owl's-eye, CMV

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Enlarged thyroid cells with ground-glass nuclei

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Orphan Annie eye- Papillary carcinoma

Front 34

Eosinphilic cytoplasmic inclusion in liver cells

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Mallory bodies- alcoholic liver disease

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Eosinophilic cytoplasmic inclusion in nerve cell

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Lewy body - Parkinson's

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Eosinophilic globule in liver

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Councilman body - toxic or viral hepatitis (often yellow fever)

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Eosinophilic inclusion bodies in cytoplasm of hippocampal nerve cells

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Rabies virus (Lyssavirus)

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Name of Rabies virus

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Lyssavirus

Front 39

Extracellular amyloid deposition in gray matter

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Senile Plaque - Alzheimers

Front 40

Giant B cells with bilobed nuclei and prominent inclusions (owl's eye)

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Reed-sternberg cells - Hodkin's

Front 41

Glomerulus-like structure surrounding vessel in germ cells

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Schiller-Duval bodies - Yolk sac tumor

Front 42

Hair on end/Crew-cut appearance on x-ray

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Extramedullary hematopoiesis (Beta-thalassemia, sickle cell anemia)

Front 43

Serum marker elevated in choriocarcinoma, hydatidiform mole

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hCG

Front 44

Inflammatory heart nodules

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Aschoff bodies (rheumatic fever)

Front 45

Heterophile antibodies

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Mononucleosis

Front 46

Hexagonal, double-pointed, needle-like crystals in bronchial secretion

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Charcot-Leyden crystals - Asthma

Front 47

Honeycomb lung on x-ray

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Interstitial fibrosis

Front 48

Hypersegmented neutrophils

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Megaloblastic anemia

Front 49

Three dx's for hypochromic, microcytic anemia

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Iron deficiency, lead poisoning, thalassemia

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Increased AFP in amniotic fluid or maternal serum

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Neural tube defect

Front 51

Intranuclear eosinophilic droplet-like bodies

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Cowdry type A bodies - HSV or yellow fever

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Iron-containing nodules in alveolar septum

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Ferruginous bodies - asbestosis

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Cancer with asbestosis

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Mesothelioma

Front 54

Large lysosomal vesicles in phagocytes + immunocompromised

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Chediak-Higashi disease (failure of phagolysosome formation)

Front 55

Low serum ceruloplasmin

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Wilson's disease

Front 56

Lumpy-bumpy appearance of glomeruli on immunoflorescence

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Immune complex deposition (i.e. poststreptococcal)

Front 57

Lytic hole punched bone lesion on x-ray

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Multiple myeloma

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Mammary gland ("blue-domed") cyst

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Fibrocystic change of breast

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3 dx's for monoclonal antibody spike

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Multiple myeloma, monoclonal gammopathy of undetermined significance, Waldenstrom's macroglobulinemia

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Antibody usually elevated with multiple myeloma

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IgG or IgA

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Antibody usually elevated with Waldenstrom's macroglobulinemia

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IgM

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Monoclonal globuline protein in blood/urine

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Bence Jones protein (myeloma), Waldenstrom's macroglobulinemia

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Mucin-filled cell with peripheral nucleus

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Signet ring

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Narrowing of bowel lumen on barium radiograph

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String sign: Chron's

Front 65

Needle-shaped, negatively birefringent crystals

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Gout

Front 66

Nodular hyaline deposits in glomeruli

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Kimmelstiel-Wilson nodules: diabetic neprhopathy

Front 67

Onion-skin periosteal reaction

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Ewing's sarcoma (malignant round-cell tumor)

Front 68

Periosteum raised from bone, creating triangular area (3 dx's)

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Codman's triangle - osteosarcoma, Ewing's sarcoma, pyogenic osteomyelitis

Front 69

Podocyte fusion on EM

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Minimal change disease

Front 70

Polished, "ivory-like" appearance of bone at cartilage erosion

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Eburnation (osteoarthritis --> sclerosis)

Front 71

Protein aggregates in neurons from hyperphosphorylation of protein tau

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Neurofibrially tangles (Alzheimers, CJD)

Front 72

Pseudopalisade tumor cell arangement

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Glioblastoma multiforme

Front 73

Rectangular, crystal-like inclusions in Leydig cells)

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Reinke crystals - Leydig cell tumor

Front 74

Rhomboid crystals, positively birefringent

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Pseudogout

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Crystal composition in pseudogout

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Calcium pyrophosphate dihydrate

Front 76

Rib notching

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Coarcation of aorta

Front 77

Sheets of medium-sized lymphoid cells, starry sky

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Burkitt's lymphoma

Front 78

Virus with Burkitt's

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EBV

Front 79

Silver-staining spherical aggregation of tau protein in neuron's

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Pick's disease

Front 80

Small, round RBC inclusions (3 dx's)

Back 80

Heinz bodies - G6PD deficiency, alpha-thalassemia, chronic liver disease

Front 81

Soap buble on x-ray

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Giant cell tumor of bone

Front 82

Spikes on basement membrane + dome-like endothelial deposits

Back 82

Membranous glomerulonephritis

Front 83

Stippled vaginal epithelial cells

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Clue cells - Gardnerella

Front 84

Tennis-racket shaped cytoplasmic organelles (EM) in Langerhans cells

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Birbeck granules - Histiocytosis X (eosinophilic granuloma)

Front 85

Thrombi made of white/red layers

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Lines of Zahn - arterial thrombosis (layers are platelets/RBC's)

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Thumb sign on lateral x-ray

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Epiglottitis (H. Influenza)

Front 87

Thyroid-like appearance of kidney

Back 87

Chronic bacterial pyelonephritis

Front 88

Tram-track appearance on LM

Back 88

Membranoprliferative glomerulonephritis

Front 89

WBC's that look "smudged"

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CLL

Front 90

Wire loop glomerular appearance

Back 90

Lupus nephropathy

Front 91

Yellow CSF

Back 91

Xanthochromia - subarachnoid hemorrhage