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7 Cards in this Set

  • Front
  • Back
Two Clotting Pathways
Intrinsic pathway
So named because everything necessary for it is in the blood.
Extrinsic pathway
So named because a cellular element outside the blood is needed. This “outside element” is the so-called tissue factor.
Anticlotting Systems- To prevent hypercoagulability
-Tissue factor pathway inhibitor (TFPI) a plasma protein
Binds to tissue factor VIIa complexes and inhibits these complexes to generate factor Xa
-Thrombomodulin
Thrombin binds and loses all clot-producing effects (see Fig. 12-78) in text
-Antithrombin III
Inactivates thrombin and other factors by binding to heparin, a substance present on surface of endothelial cells
Tissue factor pathway inhibitor (TFPI)- an anticlotting system
-a plasma protein
-binds to tissue factor VIIa complexes and inhibits these complexes to generate factor Xa
Thrombomodulin- an anticlotting system
-thrombin binds and loses all clot-producing effects
Antithrombin III- an anticlotting system
-inactivates thrombin and other factors by binding to heparin, a substance present on surface of endothelial cells
Thrombin
-an enzyme that catalyzes a reaction in which several polypeptides are split from molecules of the large rod-shaped plasma protein fibrinogen.
-The still-large fibrinogen remnants then bind to each other to form fibrin.
-The fibrin is stabilized and strengthened by covalent bond linkages (catalyzed by factor XIIIa)
Role of liver in clotting
-liver synthesizes bile salts, which go to the GI tract and it absorbs vitamin K.
-the vitamin K in the blood goes back to the liver and synthesizes clotting factors
-clotting factors are now in the blood
-vitamin K is required for the synthesis of prothrombin