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7 Cards in this Set
- Front
- Back
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T/F CML is a subtype of myeloproliferative disorder
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true
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Chronic Myelogenous Leukemia pathogenesis
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9,22 translocation -> BCR-ABL fusion protein
high tyrosine kinase activity proliferation of neutrophil cell line |
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Chronic Myelogenous Leukemia Clinical
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leukocytosis, splenomegaly, hyperleukocytosis, anemia, B-sypmtoms, Thrombocytosis
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CML vs leukomoid reaction
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LAP score low in CML
LAP score high in leukomoid reaction |
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phases of CML
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Chronic
Accelerated - Blasts >15% Blastic - Blasts > 30% |
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Treatment for CML
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Imatinib - tyrosine kinase inhibitors
occupies ATP binding pocket of Abl kinase - preventing substrate phosphorylation must continue forever |
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T315I mutation
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mutation in CML that prevents use of tyrosine kinase inhibitors
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