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7 Cards in this Set
- Front
- Back
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Causes of chronic inflammation:
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viral, persistent microbial infection, prolonged exposure to toxin, autoimmune dysfunction. (result of acute inflammation)
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Cells involved in chronic inflammation
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Macrophages and both B and T lymphocytes
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Activated macrophages produces?
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Proteases
IL-1 TNF arachidonic acid meabolites NO (IL-1 and TNF activate lymphocytes). |
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Activated lymphocytes produce
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FGF stimulates fibroblasts to produce collagen which results in scarring.
PDGF and transforming growth factor-Beta (TGF-B). Interferon-y(gamma) (activates macrophages. |
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Granulomatous inflammation
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Important type of chronic inflammation
Description: Forms a Granuloma, a collection of epitheloid histocytes (also known as macrophages) Morphology: Collection of activated macrophages; can have multinuclated giant cells. Causes: Mycobacteria, fungi, foreign material, sarcoidosis and silica. Indication: Granulomas indicate a failure to resolve by adaptive cellular mechanisms. |
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Epitheloid
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Like an epithelium
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Histocytes
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adsf
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