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13 Cards in this Set
- Front
- Back
3 similarites of Ig and TcR
2 differences |
Similariteis:
1. both in Ig domain superfamily members 2. both undergo gene rearrangement 3. both contain multigene families |
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main differences between TcR and BcR
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distinct recognition and effector mechanisms
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how many CDRs in each V chain of TcR?
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3; because two V chains, total 6 CDRs
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what do CDRs bind to?
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MHC AND ANTIGEN
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how many multigene families encode the T cell receptor?
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4; alpha, beta, delta, gamma
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gene segments for alpha and gamma:
for beta and delta: |
VJC
VDJC |
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what is the MAIN DIFFERENCE between TCR and Ig genes?
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only one or two Constant genes for TcR; no class switching, NO DIFFERENTIAL RNA PROCESSING
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3 enzymes for gene rearrangement
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Rag 1 and 2, dsbr
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difference in gene rearrangement of TcR
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additional alternative joining of D gene segment in B and delta cuz of RSS arrangement; more diversity in TCR than Antibodies.
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4 additional molecules necessary for interaction of TcR with Ag:
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CD3 complex
CD4 CD8 Adhesion Molecules - think of glue, adhesive strip |
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WHEN do adhesion molecules help TcR bind to Ag/MHC
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after interaction of the aforesaid; enhanced display of these molecules when the cell is activated allows longer tango
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allograft organ transplant
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tissue transfer between organisms of same species but different genes
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why do CTL's recognize allograft transplants, when they should only recognize SELF mhc???
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Cross-reactivity of TCR; the CTL binds to the foreign peptide/foreign MHC with LOW AFFINITY, but yet it does bind.
remember there is a lot more MHC1 on cells than MHC2; this overcomes the weak interaction. by sheer force of # |