Chpt 9

Front 1

3 similarites of Ig and TcR
2 differences

Back 1

Similariteis:
1. both in Ig domain superfamily members
2. both undergo gene rearrangement
3. both contain multigene families

Front 2

main differences between TcR and BcR

Back 2

distinct recognition and effector mechanisms

Front 3

how many CDRs in each V chain of TcR?

Back 3

3; because two V chains, total 6 CDRs

Front 4

what do CDRs bind to?

Back 4

MHC AND ANTIGEN

Front 5

how many multigene families encode the T cell receptor?

Back 5

4; alpha, beta, delta, gamma

Front 6

gene segments for alpha and gamma:

for beta and delta:

Back 6

VJC


VDJC

Front 7

what is the MAIN DIFFERENCE between TCR and Ig genes?

Back 7

only one or two Constant genes for TcR; no class switching, NO DIFFERENTIAL RNA PROCESSING

Front 8

3 enzymes for gene rearrangement

Back 8

Rag 1 and 2, dsbr

Front 9

difference in gene rearrangement of TcR

Back 9

additional alternative joining of D gene segment in B and delta cuz of RSS arrangement; more diversity in TCR than Antibodies.

Front 10

4 additional molecules necessary for interaction of TcR with Ag:

Back 10

CD3 complex
CD4
CD8
Adhesion Molecules - think of glue, adhesive strip

Front 11

WHEN do adhesion molecules help TcR bind to Ag/MHC

Back 11

after interaction of the aforesaid; enhanced display of these molecules when the cell is activated allows longer tango

Front 12

allograft organ transplant

Back 12

tissue transfer between organisms of same species but different genes

Front 13

why do CTL's recognize allograft transplants, when they should only recognize SELF mhc???

Back 13

Cross-reactivity of TCR; the CTL binds to the foreign peptide/foreign MHC with LOW AFFINITY, but yet it does bind.

remember there is a lot more MHC1 on cells than MHC2; this overcomes the weak interaction. by sheer force of #