Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
14 Cards in this Set
- Front
- Back
|
How many signals are required for activation of
-Naieve Th and Tc cells -Effector T cells (TH1, TH2, CTLs) |
Naieve require 3 signals
Effectors require only signal 1 (Ag interaction) and secrete enough of their own IL-2 to prolif/different by themselves. |
|
|
Role of Th1 cells in activating Naieve CTL-P
|
secrete IL-2 for diff/prolif of CTL
upregulate B7 on APC for enhanced co-stim signal and activation of CTL |
|
|
Fill in the blanks:CTL-P activCTL-P CTL
IL-2R expression IL-2 expression Proliferaiton Effector function |
CTL-P activated CTL-P CTL
- + + - +/- +/- - - + - - + |
|
|
Which signal is not required for activation of effector Tcells?
|
Co-stim of B7/CD28
|
|
|
Characteristics that differentiate Naieve from Effector Tcells
|
-Necessity of Co-stim signal for activ.
-Constitutive vs. induced Cell adhesion molecules -Cell trafficking patterns - what are they? -Synthesis of molecules |
|
|
Cell trafficking patterns of
-Naieve tcells -Effector t-cells |
Naieve: 2ndary lymphoid HEV
Effector: Tertiary lymph tissues, inflammatory sites- - all over |
|
|
Molecules synthesized by
-Naieve -Effector CTLs |
NAieve: nothing
Effector: CAMs, cytotoxic granules |
|
|
What component of CTLs mediates target cell damage?
|
Perforin, Granzymes
|
|
|
How does granzyme-B get from CTLs to target cells?
|
-Perforin makes pores
-Both are endocytosed by Target and then Perforin makes pores for granzyme-b to get out of granule inside target. |
|
|
what two pathways mediate apoptosis inside target cells
|
FAS pathway
Granzyme/Perforin pathway |
|
|
what do both pathways activate for apoptosis?
|
caspase pathway
|
|
|
What is the first line of defense against viral infection? why?
|
Natural Killer cells
Because they are induced by release of TNF-alpha and beta immediately following infection, and their activity climaxes at about day 3, during activation/proliferation of p-CTLs |
|
|
which cells mediate cytotoxity via ADCC?
|
NK, neutrophils, eosinophils, macrophages.
|
|
|
What is the outcome of ADCC for
NK cells Neutro/Eosino/Macroph? |
NK cells will cause apoptosis because they induce the caspase pathway with Granzymes/FAS
Neutro/Eosino/Macroph produce lytic enzymes that induce lysis nonspecifically |
