Cholinomimetic Agents

Front 1

Bethanechol

Back 1

A
Use: postoperative and Neurogenic ileus and urinary retention
Action: activates Bowel and Bladder smooth muscle; resistant to AchE.
Mnemonic: Bethany, call(Bethanechol) me if you want to activate your Bowels and Bladder

Front 2

Carbachol

Back 2

A
Use: Glaucoma,pupillary contraction, and relief of intraocular pressure.
Mnemonic: CARBon copy of acetylcholine

Front 3

Pilocarpine

Back 3

A
Use: Potent simulator of sweat, tears, saliva. And acute glaucoma.
Action: contracts ciliary muscle of eye (open angle), pupillary sphincter(narrow angle); resistant to AChE.
Mnemonic: You cry drool, and swat on your PILOw.

Front 4

Methacholine

Back 4

A
Use: challenge test for diagnosis of asthma
Action: stimulates muscarinic receptors in airway when inhaled

Front 5

Neostigmine

Back 5

B
Use: postoperative and neurogenic ileus and urinary retention, myasthenia gravis, reversal of neuromuscular junction blockade (postoperative)
Action: no CNS penetration
Mnemonic: NEO CNS = NO CNS penetration.

Front 6

Pyridostigmine

Back 6

B
Use: myasthenia gravis (lonacting) Increase strength
Action: no CNS penetration
Mnemonic: PyRIDostigmine gets RID of myasthenia gravis

Front 7

Edrophonium

Back 7

B
USE: Diagonsis of myasthenia gravis (extremely short acting)

Front 8

Physostigmine

Back 8

B
Use: Glaucoma (cross BBB --> CNS) AND atropine overdose.
Mnemonic: PHYsostigmine PHYxes atropoine overdose.

Front 9

Echothiophate

Back 9

B
Use: glaucoma

Front 10

Donepezil

Back 10

B
USE: Alzheimer's disease ( problem with decreased Ach)
Othe Alzheimer drug: Galautamine, rivastigme.

Front 11

Parathion

Back 11

C
Organophosphate poison in insecticides. Usually see poisoning in farmers.
Action: irreversibly inhibit AchE.
Sx: DUMBBELSS. Diarrhea, Urination Miosis Bronchospasm Bradycardia Excitation of seletal muscle and CNS, Lacrimation Sweating and Salivation.
Antidote - atropine and pralidoxime.

Front 12

Pralidoxime

Back 12

C
Use: organophosphate/Cholinesterase inhibitor poisoning.
Action: regenetrates active AchE