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13 Cards in this Set
- Front
- Back
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muscarinic blockers non selective
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tertiary amine (eye and cns effects) lipid soluble, well distributed in cns, quaternary amine (less cns penetration and doesn’t move acrosss lipid bilayers readily)
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use of tertiary amines
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opthalmic mydriasis and cycloplegia, fundus exams break syemchiae…. Urinary (urge incontinence, bladder spasms), GU (IBS, minor diarrhea, block muscarinic effects in periphery, parkinsons disease
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use of quarternary amines
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GU (IBS, minor diarrhea, block muscarinic effects in periphery, respiratory asthma and copd
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tertiary opthalmic
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atropine, scopalamine, cyclopentolate, tropicamide
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tertiary urinary
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oxybutynin, darifenacin, solifenacin, tolerodine
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tertiary GU
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dicylomine
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tertiary parkinsons
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benztropine, biperiden, orphenadrine, procyclidine, trihexyphenidyl
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quat GU
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glycopyrrolate, mepenzolate, methscopalamine, tridihexthyl, clinidinum, trospium, propantheline
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quat copd
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ipratopium, tiotropium
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kinetics of atropine
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liver metabolism and renal excretion,
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other clinical uses of atropine
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acls, stimulate heart rate, decrease gi motility, reduce airway secretion
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tox atropin
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"atropine fever"-- decreased sweating and lacrimation, elevation of body temp,: tachycardia, constipation, drt mouth, and blurred vision+ mydriasis. CNS--sedation, amnesia, delirium or hallucinations, heart arrhythmias, and cutaneous vasodilation; contraindicated in glaucoma, children and prostatic hyperplasia
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other clinical use scoolamine
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motion sickness
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