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28 Cards in this Set
- Front
- Back
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M1
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Found in nerves, CNS
Gq: ↑ IP3 & DAG -> ↑Ca++ |
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M2
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Cardiac mm
Gi: inhib. Adenylyl cyclase -> ↓ [cAMP] |
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M3
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Found in smooth muscle (blood vessels, GI), glands
Gq: ↑ IP3 & DAG -> ↑Ca++ |
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Acetyl Choline Cl
Receptors, Indications, Side Effects |
M + N receptors, Miosis
Very short acting (AChE) Use: Induce Miosis (for surgery) |
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Carbochol
Receptors, Indications, Side Effects |
N>M, not degraded by AChE
Use: Reduce IOP (glaucoma) |
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Bethanechol
Receptors, Indications, Side Effects |
M ONLY
Use: Urinary retention, Post-Op Ilius, Congen Mega-colon No CNS fx, SLUD |
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Cevimeline indications
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use: dry mouth w/ Sjogren's Syndrome
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Muscarine
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Mushroom poisoning (Amanita Muscarina)
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Pilocarpine
Receptors, Indications, Side Effects |
Predom. Muscarinic fx
Use: Glaucoma (↓IOP) - open and closed angle "Smacked in eye from pillow" |
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Nicotine
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Ganglionic ("Nicotinic") and CNS stim.
SE: PS & Symp effects - NVD, Tachycardia, ↑BP, CNS excitation, Convulsion & coma M. fasciculation - flaccid paralysis |
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Edrophonium
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Reversible inhib of AChE
Diagnostic for Myasthenia Gravis (temp ↑ in strength) |
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Physostigmine
Indications, effects, distribution |
Reversible inhibitor
↑ Intestinal & bladder motility, ↓ IOP, widely distrib. (incl. CNS) REDUCE CNS FX of ATROPINE hydrolyzed by AChE |
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Neostigmine
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Reversible inhib., does not enter CNS
post-op Ileus/urin. Retention, Myasthenia Gravis Destroyed by Plasma Cholinesterases (Antidote to turbocurarine?) |
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Pyridostigmine
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Reversible inhib., does not enter CNS
post-op Ileus/urin. Retention, Myasthenia Gravis Destroyed by Plasma Cholinesterases (Antidote to turbocurarine?) |
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Tacrine
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reversible inhib, lipophilic -> cross BBB, long duration of action
Delay progression of Alzheimer's Disease |
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Donepezil
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reversible inhib, lipophilic -> cross BBB, long duration of action
Delay progression of Alzheimer's Disease |
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Rivastigmine
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reversible inhib, lipophilic -> cross BBB, long duration of action
Delay progression of Alzheimer's Disease |
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Memantine
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NMDA-R antagonist
treat Alzheimer's amyloid deposition -> ↑ [Ca++] & overstim NMDA receptor -> cell death |
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Echothiophate
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organophosphate, highly polar, lipid soluble, insecticide
OD sympstoms: flaccid paralysis, SLUD, ↓ HR, BP, wheezing |
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Organophosphate OD treatment
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Atropine (muscarinic blocker) & Pralidoxime (AChE reactivator - cleaves P off)
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Malathion
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organophosphate, highly polar, lipid soluble, insecticide
OD sympstoms: flaccid paralysis, SLUD, ↓ HR, BP, wheezing |
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Tx of Dry mouth assoc. w/ Sjogren's syndrome
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Pilocarpine or cevimeline
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Tx of Cardiac arythmias (e.g. supraventricular tachycardia)
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Edrophonium
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Tx of Alzheimer's Disease
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tacrine or donepazil or rivastigmine or memantine
"Forgot to Tac Down the Riva" |
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Tx of Glaucoma
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"Physical Pilo fight hit in eye (Glaucoma), jumped in Car and eye Echo'd c/o so swollen"
Physostigmine, pilocarpine, carbachol, echothiophate |
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Tx of Urinary retention or POI (Post-Op Ileus)
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"After surgery, Beth made me a New (Neo) man Physically"
Bethanechol, Neostigmine, Physostigmine |
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Tx of Myasthenia Gravis
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"My Grandpa Edy went to see the New (Neo) Pyramids"
Edrophonium (diagnostic), Neostigmine, Pyridostigmine |
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Antagonize Atropine
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Physostigmine
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