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24 Cards in this Set

  • Front
  • Back
Cholinomimetics- direct
bethanechol, carbachol, pilocarpine, methacholine
Cholinomimetics- indirect
neostigmine, pyridostigmine, edrophonium, physostigmine, echothiophate, donepezil, rivastigmine, galantamine, tacrin
how do the indirects work?
bethanechol uses
post op and neurogenic ileus and urinary retention
carbachol uses
glaucoma, pupillary contraction, and release of intraocular pressure
pilocarpine uses
potent stimulator of sweat, tears, saliva
methacholine use
challenge test for asthma
neostigmine uses
postop and neurogenic ileus and urinary retention, MG, reversal of NMJ blockade (postop)
Pyridostigmine uses
MG, does not penetrate CNS
Edrophonium use
Dx of MG
Physostigmine use
glaucoma, atropine OD, crosses BBB
Echothiophate use
Cholinesterase inhibitor poisoning (also seen with organophosphates)
Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of skeletal muscle and CNS, lacrimation, sweating, salivation
Antidote for cholinesterase poisoning
atropine (muscarinic antagonist) plus pralidoxime (regenerate active cholinesterase)
atropine, homatropine, tropicamide uses
produce mydriasis and cycloplegia
benzotropine uses
scopolamine use
motion sickness
ipratropium uses
asthma, COPD
methscopolamine, oxybutin, glycopyrrolate uses
reduce urgency in mild cystitis and reduce bladder spasms
glaucoma drug classes
A-ag, B-block, cholinomimetics, diuretics, prostaglandins
ganglionic/nicotinic blocker
Atropine effects
increase pupil dilation, cylcoplegia; decrease secretions; decrease acid secretion; decrease motility; decrease urgency in cystitis
Atropine toxicity
hot as a hare, dry as a bone, red as a beet, blind as a bat, mad as a hatter, bloated as a toad, tachycardia
Atropine AE
acute angle closure glaucoma in elderly, urinary retention in men with prostatic hypertrophy, hyperthermia