Cholinergic And Adrenergic Pharmacology

Front 1

When you can't pee, can't poop, who do you call? What are the two circumstances in which this drug is used?

Back 1

Bethanochol! M3 agonist. Treats: post-operative ilius and urinary retention

Front 2

Treats Sjorgen's xerostomia, radiation-induced xerostomia and glaucome

Back 2

Pilocarpine

Front 3

Three drugs used to treat glaucoma + their mechanisms

Back 3

1. Pilocarpine = M3 agonist - contracts ciliary and constrictor pupillae to enhance water removal
2. Physostigmine = little known fact - "stigmine" means "carbamylating inhibitor of acetylcholinesterase" in Greek. Not really. But that's what it does - and as such, though its T1/2 is short, it cannot be nudged off by pralidoxime. Treat overdose with atropine only.
3. Echothiophate = It has a phosphate group and a thiol group, and 'echo' is actually Greek for 'I have'. 'I have a thiol and a phosphate' - this is a dangerous, long-lasting phosphorylating agent is nonetheless effective at treating glaucoma. Treat overdoses with both pralidoxime and atropine.

Front 4

This drug is used to help sufferers of Myasthenia Gravis climb pyramids! (JK, it's designed to help them move - but theoretically, they could climb pyramids if they wanted to.)

Back 4

Pyridostigmine

Front 5

Non-covalent (short-lived) binding to AChE, but capable of crossing the blood-brain barrier (BBB)

Back 5

Donezepil
This is a slightly horrible mnemonic - but I imagine a French/Spanish/English combo old man asking, 'Don(de) ez the pill?' This is how I remember than donezepil, despite its short-lived interaction with the central AchE, is effective at treating Alzheimer's disease.

Front 6

Malathion toxicity is usually treated with...

Back 6

...atropine!

Front 7

And atropine toxicity is usually treated with...

Back 7

...physostigmine!

Front 8

Physostigmine is used to treat what condition (other than atropine toxicity)? What is its mechanism?

Back 8

Glaucoma (carbamylating AChE inhibitor)

Front 9

What two other drugs are used to treat glaucoma, besides physostigmine?

Back 9

Echothiophate (phosphorylating AChE inhibitor)

Pilocarpine (M3 agonist)

Front 10

What M2 antagonist is used to treat Malathion-induced bradycardia?

Back 10

Atropine

Front 11

What M3 antagonist is used to treat COPD (in chronic form), and a less serious condition with a silly name that Sam is amused by? What is that less serious condition?

Back 11

Ipratomium, rhinorrhea

Front 12

Motion sickness, M3 Antagonist

Back 12

Scopolamine

Front 13

2 drugs used to treat incontinence/frequent urination

Back 13

Oxybutinin

Tolterodine