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20 Cards in this Set

  • Front
  • Back
Botulinum Toxin
Enters cholinergic nerve terminal and destroys proteins involved in exocytotic ACh release.
*Local admin. only
Muscarine
Muscarinic receptor agonist
Pilocarpine
Muscarinic receptor agonist

Tx: Glaucoma, Dry Mouth
Bethanechol
ACh analog

Uses: GI stimulation, and to treat urinary retention
Methacholine
ACh analog

test for hyperactive airways
Atropine
Competitive antagonist at all muscarinic receptors
Scopolamine
Antimuscarinic w/ more CNS action than Atropine (more lipophillic than atropine)

Uses: Motion Sickness
Ipratropium
Antimuscarinic that stays in the lungs when inhaled (less lipophillic than atropine)

Uses: COPD & Asthma
Tolterodine
Antimuscarinic that has apparent selectivity for the bladder

Uses: Relax the bladder
Nicotine
Nicotinic receptor agonist

Uses: Works on neuromuscular junction and ganglia
*Can have blockade effect a [high]
Varenicline
Nicotinic receptor partial agonist

*Can induce suicidle thoughts in susceptible patients
Hexamethonium
ACh antagonist at nicotinic receptors
"Ganglionic Blocker"

Blocks entire Autonomic Nervous System
Mecamylamine
ACh antagonist at nicotinic receptors
"Ganglionic Blocker"

Blocks entire Autonomic Nervous System
Edrophonium
"tensilon"
Reversible ACh E competitive inhibitor
Physostigmine
ACh E substrate inhibitor
-is broken down by AChE
Neostigmine
ACh E substrate inhibitor
-is broken down by AChE
Echothiophate
Irreversible ACh E inhibitor
"Organophosphates"
Sarin/ VX
organophosphate permanent ACh E inhibitor
Pralidoxime (2-PAM)
Regenerates active ACh E
-Give with organophosphate tox
Parathion

Malathion
Organophosphate