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20 Cards in this Set
- Front
- Back
Botulinum Toxin
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Enters cholinergic nerve terminal and destroys proteins involved in exocytotic ACh release.
*Local admin. only |
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Muscarine
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Muscarinic receptor agonist
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Pilocarpine
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Muscarinic receptor agonist
Tx: Glaucoma, Dry Mouth |
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Bethanechol
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ACh analog
Uses: GI stimulation, and to treat urinary retention |
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Methacholine
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ACh analog
test for hyperactive airways |
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Atropine
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Competitive antagonist at all muscarinic receptors
|
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Scopolamine
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Antimuscarinic w/ more CNS action than Atropine (more lipophillic than atropine)
Uses: Motion Sickness |
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Ipratropium
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Antimuscarinic that stays in the lungs when inhaled (less lipophillic than atropine)
Uses: COPD & Asthma |
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Tolterodine
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Antimuscarinic that has apparent selectivity for the bladder
Uses: Relax the bladder |
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Nicotine
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Nicotinic receptor agonist
Uses: Works on neuromuscular junction and ganglia *Can have blockade effect a [high] |
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Varenicline
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Nicotinic receptor partial agonist
*Can induce suicidle thoughts in susceptible patients |
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Hexamethonium
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ACh antagonist at nicotinic receptors
"Ganglionic Blocker" Blocks entire Autonomic Nervous System |
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Mecamylamine
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ACh antagonist at nicotinic receptors
"Ganglionic Blocker" Blocks entire Autonomic Nervous System |
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Edrophonium
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"tensilon"
Reversible ACh E competitive inhibitor |
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Physostigmine
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ACh E substrate inhibitor
-is broken down by AChE |
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Neostigmine
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ACh E substrate inhibitor
-is broken down by AChE |
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Echothiophate
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Irreversible ACh E inhibitor
"Organophosphates" |
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Sarin/ VX
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organophosphate permanent ACh E inhibitor
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Pralidoxime (2-PAM)
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Regenerates active ACh E
-Give with organophosphate tox |
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Parathion
Malathion |
Organophosphate
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