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25 Cards in this Set

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  • Back
Most cholesterol comes from ____ production and consumption of ____.
endogenous
saturated and trans fats
What is a enzyme involved in cholesterol production?
HMG-CoA reductase
Apolipoprotein B-100 delivers cholesterol to the ____ while apolipoprotein A-I delivers cholesterol to the ____.
Nonhepatic Tissues
Liver
Which is the worst type of cholesterol?
LDL
Cholesterol levels play a role in _____.
Atherosclerosis, CHD
Optimal Cholesterol Levels:
LDL less than 100
HDL greater than 40
What is Metabolic Syndrome?
Abdominal Fat
High Cholesterol Levels
Hyperglycemia
High BP
HMG-CoA reductase inhibitors are known as ____.
Statins
If the the drug ends in -astatin it is a ____.
Statin
Statins are most effective when given in the morning.
T or F
False
Evening is most effective
Cholesterol lowering drugs are life long treatments.
T or F
True
What statin reaches abnormally higher levels in Asians?
Rosuvastatin
What are the adverse effects of statins?
Myopathy
Hepatotoxicity
Fetal Harm (Category X)
Nicotinic Acid is ____ and is used to ____.
Niacin
Lower cholesterol
Niacin causes a fall in HDL.
T or F
False
Niacin causes a reduction in VLDLs which reduce LDLs
What is the adverse effect of Nicotinic Acid?
Flushing and Itching
What are the three Bile-Acid Sequestrants?
Cholestyramine
Colestipol
Colesevelam
What is the action of Bile-acid Sequestrants and Statins?
increase LDL receptors on hepatocytes
What are adverse effects of Bile-acid sequestrants?
GI effects
Fibric Acid Derivatives are known as ___.
Fibrates
Fibrates reduce LDL levels.
T or F
False
Decrease VLDL and increase HDL
What are the adverse effects of Fibrates?
GI effects
Gallstones
Myopathy
Liver Injury
Fenofibrate is a ___.
Fibrate
What is Gemfibrozil?
Fibric Acid Derivative
What is the action of Ezetimibe?
Blocks cholesterol absorption