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25 Cards in this Set
- Front
- Back
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Most cholesterol comes from ____ production and consumption of ____.
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endogenous
saturated and trans fats |
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What is a enzyme involved in cholesterol production?
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HMG-CoA reductase
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Apolipoprotein B-100 delivers cholesterol to the ____ while apolipoprotein A-I delivers cholesterol to the ____.
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Nonhepatic Tissues
Liver |
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Which is the worst type of cholesterol?
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LDL
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Cholesterol levels play a role in _____.
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Atherosclerosis, CHD
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Optimal Cholesterol Levels:
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LDL less than 100
HDL greater than 40 |
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What is Metabolic Syndrome?
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Abdominal Fat
High Cholesterol Levels Hyperglycemia High BP |
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HMG-CoA reductase inhibitors are known as ____.
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Statins
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If the the drug ends in -astatin it is a ____.
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Statin
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Statins are most effective when given in the morning.
T or F |
False
Evening is most effective |
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Cholesterol lowering drugs are life long treatments.
T or F |
True
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What statin reaches abnormally higher levels in Asians?
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Rosuvastatin
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What are the adverse effects of statins?
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Myopathy
Hepatotoxicity Fetal Harm (Category X) |
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Nicotinic Acid is ____ and is used to ____.
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Niacin
Lower cholesterol |
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Niacin causes a fall in HDL.
T or F |
False
Niacin causes a reduction in VLDLs which reduce LDLs |
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What is the adverse effect of Nicotinic Acid?
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Flushing and Itching
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What are the three Bile-Acid Sequestrants?
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Cholestyramine
Colestipol Colesevelam |
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What is the action of Bile-acid Sequestrants and Statins?
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increase LDL receptors on hepatocytes
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What are adverse effects of Bile-acid sequestrants?
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GI effects
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Fibric Acid Derivatives are known as ___.
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Fibrates
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Fibrates reduce LDL levels.
T or F |
False
Decrease VLDL and increase HDL |
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What are the adverse effects of Fibrates?
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GI effects
Gallstones Myopathy Liver Injury |
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Fenofibrate is a ___.
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Fibrate
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What is Gemfibrozil?
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Fibric Acid Derivative
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What is the action of Ezetimibe?
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Blocks cholesterol absorption
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