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30 Cards in this Set
- Front
- Back
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Vibrio cholerae: Do they have a flagella?
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Yes, single
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V. cholerae: how do they attach to cells?
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pili
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V. cholerae:: What molecule is used to classify different serogroups?
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LPS
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V. cholerae: Which 2 serogroups cause epidemic disease?
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O1 and O139
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V. cholerae: Are they susceptible to gastric acid?
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yes
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V. cholerae: What are the major sources of infection?
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water and food
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V. cholerae: What is the severe manifestation of this disease?
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- rice water diarrhea
- no blood or pus - extreme dehydration (loss up to 1L/hr) |
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V. cholerae: How long after ingestion before symptoms?
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2-3 days
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V. cholerae: How does it get into the host GI?
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large quantities orally
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V. cholerae: How are they internalized by the host?
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- mucinase and flagella fac. penetration of mucosa
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V. cholerae: Is the bug invasive?
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no
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V. cholerae: Where do the VFs come from?
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lysogenic phage
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V. cholerae: What is the major VF?
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cholera toxin
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V. cholerae: How does cholera toxin increase cAMP
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B subunit: binds to ganglioside receptor, allows A entrance
A subunit: activates Gs |
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V. cholerae: What bacteria has a toxin similar to this bug?
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ETEC
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V. cholerae: What 3 things do Vibrio and ETEC have in common?
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1. watery diarrhea
2. some ETECs have cholera toxin 3. pili |
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V. cholerae: What 2 things are different between cholera and ETEC?
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1. cholera = 1 toxin, ETEC = LT and ST
2. cholera toxin = lysogenic phage encoded, ETEC = plasmid |
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Yersinia pestis: What disease doesthis most commonly cause?
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plague
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Y. pestis: What spreads urban plague?
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rats
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Y. pestis: What spreads sylvanic plague?
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squirrels, rabbits, cats
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Y. pestis: Are humans accidental or intentional hosts?
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accidental
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Y. pestis: How is this bug spread?
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animal to human by flea or contact
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Y. pestis: What are the 2 systemic types of plague?
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1. Bubonic
2. Pneumonic |
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Y. pestis: Bubonic plague resides in what organ and spreads via what system?
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LN; lymphatics
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Y. pestis: Pneumonic plague is in what organ and is acquired by what mechanism?
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lungs, aerosol
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Y. pestis: What is the incubation time for Bubonic and Pneumonic plague, respectively?
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1 week and 2 days
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Y. pestis: Which type of plague is referred to as black death?
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Pneumonic plague due to purpuric lesions
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Y. pestis: Can Bubonic plague become Pneumonic plague?
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Yes, if it spreads in the blood to the liungs
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Y. pestis: Which type of plague is highly contageous?
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Pneumonic plague
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Y. pestis: How do these bugs avoid phagocytosis?
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1. inhib phagocytes directly
2. disrupt phagocytes 3. induce macro apoptosis 4. suppress cytokine production |
