Chloramphenicol, Tetracyclines, Macrolides, Clindamycin

Front 1

Adverse Effects of Linezolid

Back 1

Thrombocytopenia and Nuetropenia

Front 2

Antibiotic that binds to a unique site located on the 23S ribosomal RNA of the 50S ribosomal subunit. Currently there is no cross resistance with other protein synthesis inhibitors

Back 2

Linezolid

Front 3

Antibiotics that are potent inhibitors of CYP3A4 and increase plasma levels of many drugs (astemizole, cisapride, cyclosporine, diazepam, NNRTI, Warfarin)

Back 3

Streptogramins

Front 4

Toxicity of Clindamycin

Back 4

GI irritation, skin rashes, neutropenia, hepatic dysfunction, and possible superinfections w/ C. difficile and pseudomembranous colitis

Front 5

Main clinical use of clindamycin

Back 5

Severe infections caused by certain anaerobes such as Bacteroides

Front 6

Macrolide that inhibits several forms of hepatic cytochrome P450 and can increase the plasma levels of anticoagulants, carbamazepine, cisapride, digoxin, and theophylline

Back 6

Erythromycin

Front 7

Macrolide that can cause a hypersensitivity based acute cholestatic hepatitis

Back 7

Erythromycin

Front 8

Macrolide with the longest half-life

Back 8

Azithromycin (permits once daily dosing)

Front 9

Elimination of clarithromycin

Back 9

Hepatic metabolism and urinary excretion of intact drug

Front 10

Elimination of erythromycin

Back 10

Biliary Excretion

Front 11

Tetracycline that causes sensitivity to UV light

Back 11

Demeclocycline

Front 12

Fanconi's syndrome is attributed to the use of these outdated anti-microbials

Back 12

Tetracyclines

Front 13

Drugs that at high doses, especially in pregnant women and those with preexisting hepatic disease, that may impair liver function and lead to hepatic necrosis

Back 13

Tetracyclines

Front 14

Drug with broad spectrum of action including against MRSA and VRE strains, beta-lactamase producing gram-negative bacteria, anaerobes, chlamydiae, and mycobacteria

Back 14

Tigecycline

Front 15

Selective use of Demeclocycline

Back 15

Inhibits the renal actions of ADH and is used in the management of patients with ADH secreting tumors

Front 16

Selective uses of Doxycycline

Back 16

Lyme disease, prevention of malaria, and treatment of amebiasis

Front 17

Primary uses of tetracyclines

Back 17

Mycoplasma pneumoniae, Chlamydia, Rickettsia, and Vibrio species
-Doxycycline is currently an alternate to macrolides in the TX or CAP

Front 18

Mechanism of resistance to Tetracyclines

Back 18

Efflux pumps

Front 19

Toxicity of Chloramphenicol

Back 19

GI disturbances, inhibition of red cell maturation leading to a decrease in circulating erythrocytes, aplastic anemia is a rare idiosyncratic reaction; Gray baby syndrome and drug interactions

Front 20

Clinical uses of Chloramphenicol

Back 20

Backup drug for severe infections of Salmonella species and for the treatment of pneumococcal and meningococcal meningitis in beta lactam sensitive person
-A commonly used topical antimicrobial

Front 21

Drug that is usually bacteriostatic. Resistance is plasmid mediated, occurs through the formation of acetyltransferases that inactivate the drug

Back 21

Chloramphenicol

Front 22

MOA of Linezolid

Back 22

Bacteriostatic; binds to a unique site on the 50S ribosome, inhibiting initiation by blocking formation of the tRNA-ribosome-mRNA ternary complexes

Front 23

MOA of streptogramins

Back 23

Bind to the 50S ribosomal subunit, constricting the exit channel on the ribosome through which nascent polypeptides are extruded. tRNA synthetase activity is also inhibited, leading to a decrease in free tRNA within the cell

Front 24

MOA of Tetracyclines

Back 24

Bind to the 30S ribosomal sub-unit, preventing binding of amino acid charged tRNA to the acceptor site of the ribosome-mRNA complex

Front 25

MOA of chloramphenicol

Back 25

Inhibits transpeptidation by blocking the binding of the aminoacyl moiety of the charged tRNA molecule on the acceptor site on the ribosome-mRNA complex

Front 26

Binding sites for chloramphenicol, macrolides, clindamycin (microbial protein synthesis inhibitors)

Back 26

50s ribosomal subunit

Front 27

Drugs notorious for causing pseudomembranous colitis

Back 27

Clindamycin

Front 28

Drug that causes gray baby syndrome and aplastic anemia

Back 28

Chloramphenicol

Front 29

MOA of tetracycline

Back 29

Decrease protein synthesis by inhibiting 30S ribosome

Front 30

Drugs that cause teeth discoloration

Back 30

Tetracycline