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26 Cards in this Set
- Front
- Back
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What disease are chlamydia responsible?
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trachoma, lymphgranuloma venereum, nongonococcal urethritis, mucopurulent cervicitis, pelvic inflammatory disease, ornithosis, psittacosis, pneumonia
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Obligate Intracellular parasites, gram -, cytoplasmic/outer membranes, lack peptidoglycan, disulfide cross linked proteins (pg-like), nonmotile, coccobacilli, divide by binary division, energy parasites
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Chlamydia
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What is the developmental cycle of chlamydia?
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Elementary Body - extracellular survival
reticulate Body - intracellular multiplication Stain Both wit Giemsa |
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Chlamydia are adapetd to intracellular environment, survive _____, inhibits ____ _____, and avoid ______ enzymes
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Phagocytosis
DNA Synthesis lysozyme |
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C. psittaci, C. trachomatis, C. pneumoniae
Which one is Glycogen + |
C. trachomatis
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How do u test for Glycogen?
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add Iodine
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______ _______ causes acute respiratory infections, transmitted in feces of birds
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C. psittaci
- ornithosis - psittacosis |
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_______ _______ causes chronic conjuctivitis and sexually trasnmitted lymphogranuloma venereum
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C. trachomatics
- serovar A, B1, B2, C |
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________ ______ causes pneumonia (TWAR Strain) and inclusion conjuctivitis
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C. pneumoniae
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Eye Disease, non-systemic, greatest single cause of blindness, infects the epithelial lining. transmitted finger to eye contact
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Trachoma
- C. trachomatis |
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Pathogenesis of Trachoma
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Abrupt, inflamed conjuctiva, accumulation of lymphocytes/PMNs form follicles beneath the cunjuctival surface.
Mucopurulent disharge, eyelash follicular hypertrophy, swollen inflamed capillaries. Roughened Conjuctival Surface, eyelids can turn inward. |
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In populations where trachoma is endemic ____% of the population recovers without serious problems.
Two antibodies: __ and __ |
90%
IgG sIgA |
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Diagnosis of Trachoma
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1. Agent is isolated from conjunctival scrapings, growth in cell culture, McCoy Cells
2. Cytoplasmic Inclusion bodies found in conjuctival cells 3. Test Eye secretions 4. Stain inclusiion bodies with Iodine (Glycogen) 5. Immunoflourescence test |
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Treatment of Trachoma
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Sulfonamides, tetracycline, ophthalmic oointments
1. Surgery 2. Antibiotic 3. Facial Cleanliness 4. environmental Changes |
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Infants: conjuctiva inflamed and thicken, discharge of pus, no corneal scarring.
Adults: resembles trachoma |
Inclusion conjuctivitis
Infants: ophthalmic AgNO3 drops, 0.5% erythromycin ointment, 1% tetracycline ointment Adults: tetracycline C. trachomatis |
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Males: Genital Lesions, adenopathy (swelling of lymph), enlarged tender buboes, fever, headache, malaise.
Females: swollen labia, blood/pus from rectum |
Lymphogranuloma Venereum
Tetracycline C. trachomatis |
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Female Counterpart of NGU, grows on epithelial cells of endocervix/rectum, can lead to PID.
Detection? |
'Swab' test
- yellow green mucous on a white cotton swab C. trachomatis |
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Mild Symptoms, pelvic-abdominal pain, infertility, can lead to endometritis/peritonitis
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Pelvic Inflammatory Disease
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Young Healthy Females, sterile urine, dysuria/pyuria
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Acute Urethral Syndrome
c. trachomatis |
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Transmitted via anal intercourse, watery discharge
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Proctolitis
C. trachomatis |
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Parasite of Psittacine birds, transmitted through bird feces.
Birds: ornithosis, psittacosis Humans: zoonotic pneumonia |
C. psittaci
tetracycline in bird feeds |
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Humans: enters via mucosal respiratory cells, carried by macrophages to liver/spleen. disseminates through the blood stream.
Nausea, vomiting, fever, headache. Hacking non-productive cough and pneumonia |
Psittacosis (PArrot Fever)
Treatment: tetracycline, deoxycycline, erythromycin |
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Where did the TWAR strain name come from?
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Eye isolate from a child in Taiwan, TW-183.
Throat swab from a child with pharyngitis, AR-39 |
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Typically in teens, causes atypical pneumonia, pharyngitis, bronchitis.
cough, low-grade fever, hoarseness, sore throat. |
C. pneumoniae
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Pathogenesis of C. pneumoniae
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Adhere and damage endothelial cells, ilicit a strong inflammatory response, transmission through aerosol.
Tied to heart disease (infects endothelial cells), creates a zone of inflammation and dammages blood vessel wall - cholesterol plaques. |
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C. pneumoniae causes __% of all bronchitis, and _% of sinusitis
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45
5 Tetracycline |
