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20 Cards in this Set
- Front
- Back
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Why is Pegfilgrastim better than Filgrastim
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Peg is only give 1 time
incidence of neutropenia is at least equal if not less with Peg |
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How are Pegfilgrastim and Filgrastim comprable
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comprable neutrophil recovery
reducing severity and possible incidence neutropenia duration of severe neutropenia is same bone pain incidence |
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Thrombocytopenia is when
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platlets are <150,000/uL
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when do you give a blood transfustion in cancer induced anemia
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severe neutropenia - Grade 3-4
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when do you use EPO or darbopoeitin alfa
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Grade 1-2 anemia
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when using EPO in cancer-induced anemia what 4 things to keep in mind
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hemoglobin goal 10-12
for trt of anemia WHILE recieving chemotherapy for NON-curable stop using when not giving chemo |
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neutropenia is when
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Mild neutropenia (1000 <= ANC < 1500) — minimal risk of infection
Moderate neutropenia (500 <= ANC < 1000) — moderate risk of infection Severe neutropenia (ANC < 500) — severe risk of infection. |
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how do you calculate ANC
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ANC = WBC x (% neutrophil + % bands)
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Do using colony stimulating factors increase neutropenic days and increase chance of survival
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No it does neither. CSFs decrease number of neutropenic days after chemo and neither change survival
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At what platlet levelis there a risk of bleeding secondary to traumatic injury
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40,000 - 60,000/µL
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at what platlet level is spontaneous bleeidng a concern
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less than 20,000/uL
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as platlet counts decrease bleeding time______
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increases
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what things lead to decreased platlet production
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drugs
infection nutritional defects- don't have the building blocks radiation |
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what things lead to platlet destruction
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drug-induced
alloimmune autoimmune (ITP) Consumptive (TTP, HUS, DIC) |
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when do you give platlet transfusions in
uncomplicated pt active bleed surgery pts |
less than 20,000/uL
30,000-50,000/uL less than 70,000/uL |
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what is Oprelvekin
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cytokine - recombinant interleukin 11 used to prevent thrombocytopenia, is rarely used due to ADR
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what is the main treatment for bone pain
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NSAID/APAP
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what are your treatement options for neutropenia
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Decrease Dose of chemotherapy
Sargramostim (Leukine, GM-CSF) Filgrastim (Neupogen, G-CSF) Pegfilgrastim (Neulasta, pegG-CSF) |
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what are your treatment options for thrombocytopenia
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platlet infusions
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what can oprelvekin be used for
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prevention of thrombocytopenia
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