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105 Cards in this Set
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- 3rd side (hint)
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Alkylating Agents
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Methylmelamines & Ethylenimines
Alkyl sulfonates Nitrosureas Nitrogen Mustard |
MANN
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Nitrogen Mustards
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Mechlorethamine
Melphalan Ifosfamide Cyclophosphamide Chlorambucil |
MMICC
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Methylmelamines & Ethylenimines
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Altretamine
Thiotepa |
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Alkyl sulfonates
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Busulfan
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-SULFAN
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Nitrosureas
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Carmustine
Streptozocin Polifeprosan 20 |
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Hydration and mesna therapy are recommended for
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Cyclophosphamide and ifosfamide
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A nitrosureas that can cause pulmonary fibrosis
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Carmustine
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Ifosfamide adverse effect
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encephalopathy
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Polifeprosan/carmustine can induce
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seizures
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Monitoring parameters for Alkylating agents
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Pulmonary fxn, chest x-ray
Renal & hepatic CBC w/ diff & lytes urinalysis (for RBC) Bleeding Infection N/V |
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Antimetabolites
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Folic acid antagonists
Pyrimidine analogs Purine analogs |
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Folic acid antagonists
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Pemitrexed
Methotrexate |
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Pyrimidine analogs
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CytaraBINE
CapeCITABINE (Xeloda) AzaCITIDINE GemCITABINE DeCITABINE 5-FU |
CCAGeD...FU!
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Purine analogs
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Clofarabine
MercaptoPURINE ThioGUANINE Pentostatin Cladribine Fludarabine |
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To reduce damage to the mucosal lining in your mouth, you may be asked to chew ice if you are receiving
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5-FU
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If you have pain, swelling, or tingling in your palms or soles of your feet, you are probably taking what drug?
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5-FU
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Hand foot syndrome
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You may have trouble urinating if you are on
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clofarabine
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a purine analog
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What two injections should a patient receiving if they are on pemetrexed
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Folic acid and vitamin B12
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3 chemo agents from the antimetabolite class that may cause neurotoxicity
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cytarbine
fludarabine methotrexate |
one from each group!
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Flu like symptoms and hemolytic uremic syndrome from a pyrimidine analog
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gemcitabine
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Conjunctivitis is an ADR from
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cytarabine
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What chemo agent may cause tumor lysis syndrome, SIRS, or capillary leak?
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clofarabine
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Opportunistic infections are very common with what two antimetabolites?
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Cladribine
Fludarabine |
Purine analogs
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This antimetabolite should inclue INR in the monitoring parameters
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capecitabine (xeloda)
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This antimetabolie should include diarrhea, janundice, and hepatomegaly in the monitoring parameters
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Mercaptopurine
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Clofarabine sounds pretty bad with the SIRS and all. What are three things that each patient on this should get?
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Continuous IV fluids
Allopurinol Corticosteroids |
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What two things should a pt with pemetrexed get?
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Plasma homocysteine
Dexamethasone |
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Antitumor antibiotics
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Anthracyclines
Alkylting-LIKE Chromomycin Bleomycin |
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Change of urine color or whites of eyes to a bluish-green or orangish-red are d/t
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anthracyclines
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Cardiac toxicity
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Anthracyclines
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Anthracyclines have limits on _______ lifetime dosing
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CUMULATIVE
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Are anthracyclines vesicants?
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yep
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Can anthracyclines cause any kind of secondary leukemia?
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Acute myelogenous leukemia (AML)
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yes....name it
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Pulmonary fibrosis and intersitial pneumonitis is common with what antitumor ATB?
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Bleomycin
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Anthracycline dosing is adjusted based on elevated
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TOTAL bilirubin
and, therefore, adjust w/ hepatic impairment |
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Anthracyclines
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Doxorubicin
Daunorubicin Epirubicin Idarubicin Valrubicin Mitoxantrone |
Most end in rubicin
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Alkylating-lik
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Mitomycin
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Chromomycin
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Dactinomycin
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Bleomycin is _______ excreted
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renally
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Hormones and antagonists
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Adrencorticoids
Progestins Estrogens Antiestrogen Aromatase inhibitors Androgens Antiandrognes LHRH agonists GNRH agonst |
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Adrenocorticoids
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Aminoglutethimide
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Progestins
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Megestrol acetate (Megace)
Medroxyprogesterone |
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Estrogens
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Ethinyl estradiol
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Anti-estrogen
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Tamoxifen
Fulvestrant Toremifene |
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Aromatase inhibitors
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Exemestane
Anastrozole Letrozole |
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Androgens
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Testosterone
Fluoxymesterone |
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Anti-androgens
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Flutamide
Vicalutamide Nilutamide |
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LHRH agonsits
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Triptorelin
Leuprolide Goserelin |
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GNRH agonist
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Abarelix
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hormones and pregnancy
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NO
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Hormones may cause weight _____
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GAIN
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Leg swelling or tenderness may be signs of what
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DVT
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Transisent muscle or bone pain
problems urinating spinal cord compression |
LHRH agonsits
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Abarelix's BLACK BOX WARNING:
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Hypotension and syncope
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Endometrial cancer may be a ADE for
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tamoxifen
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Exemestance should be taken with what regard to food?
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after meals
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Bone loss
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LHRH
aromatase inhibitors |
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The majority of hormone therapy is ______ available
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oral
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Contraindication for hormones
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More than one type of hormone-dependent tumor
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Plant alklaoids
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taxanes
epipodophyllotoxins camptothecins vinca alkaloids |
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Taxanes
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Docetaxel
Paclitaxel |
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Epipodophyllotoxins
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Etoposide
Teniposide |
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Camptothecins
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Irinotecan
Topotecan |
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Vinca alkaloids
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Vincristine
Vinblastine Vinorelbine |
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Prophylaxis for emesis
Pretreatment for anapylaxis or peripheral edema |
taxanes
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With irinotecan therpay, you should get an RX for what?
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Loperamide and atropine
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Neurotoxicity
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vincristine
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Syndrome of inappropriate ADH secretion
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vinca alkaloids
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Drug resistance for plant alkaloids
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p-glycoprotein pumps
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Topotecan needs dose adjustments for patients w/ a CrCl <=
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40 ml/ml
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Are vincas vesicants?
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YES
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Bilogic response modifiers and monoclonal antibodies
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Immune therapies
Monoclonal antibodies |
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Immunie therapies
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Aldesleukin
Interferon-alfa 2b Levamisole |
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Monoclonal antibodies
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----MAB
denileukin diftitox |
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Biologic responspe modifiers have a direct biological effect on
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malignancies
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Monoclonal antibodies bind to specific antigens and kill cells through....
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activation of apoptosis
complement-mediated lysis |
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Monoclonal antibodies can cause infusion-related reactions such as
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fever and chills
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Monitoring for Bevacizumab
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BP checked and protien in urine
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Cetuximab
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photosenstive
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Tositumomab
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check thyroid
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Tumor lysis syndrome with what monoclonal antibody
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rituximab
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Adverse reactions of bevacizumab
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bleeding, hemorrhage
HTN proteinuria skin rash |
4
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Cutaneous and sever infusion RXNS
intersitial lund disease |
cetuximab
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hypothyroidism (mab)
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tositumomab
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Monoclonal ATB should be premedicated with
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APAP and diphenhydramine
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Cetuximab and ibritumomab can cause
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TROUBLE BREATHING
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Platinum compounds
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Cisplatin
Carboplatin Oxaliplatin |
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Adverse effects of platinum
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nephrotox
peripheral neurotox myelosuppression ototox N/V |
4 things
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which platinum needs hydration therapy and premedication
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CISplatin
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Which plantin should be monitored for thrombocytopenia
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CARBOplantin
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Which platinum has unique neurotoxicities such as bronchial spams
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oxaliplatin
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Asparaginase MOA
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removes asparagines from leukemic cells
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Intradermal skin testing w/ asparaginase b/c...
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sever anaphylatic rxns
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Asparaginase SE
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melosuppression
hyperuricemia hyperglycemia renal |
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Hydroxyurea SE
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secondary leukemias
N/V/D/C mucositis ***rare fatal hepatotox and pancreatitis |
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Imatinib
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PHILADELPHIA CHROMOSOME
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Imatinib ADR
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hepatotox
FLUID RETENTION neutropenia |
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Erlotinib
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HER-1 receptor
EGFR |
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Highly to moderately emetogenic
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Dexamethasone
5-HT3 antagonists *consider aprepitant |
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Low to unlikely emetogenic
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dexamethasone
phenothiazine |
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delayed CINV
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metoclopramide
dexamethasone |
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What vaccines should chemo pts NOT get?
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live and rotavirus
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5-HT3 antagonists
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dolasetron (Anzemet)
Granisetron (Kytril) Ondansetron (Zofran) Palonosetron (Aloxi) |
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Phenothiazines
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Prochlorperazine (Compazine)
Chlorpromazine (Thorazine) Promethazine (Phenergan) |
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Neurokinin-1 antagonist
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Aprepitant (Emend)
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