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105 Cards in this Set

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Alkylating Agents
Methylmelamines & Ethylenimines
Alkyl sulfonates
Nitrosureas
Nitrogen Mustard
MANN
Nitrogen Mustards
Mechlorethamine
Melphalan
Ifosfamide
Cyclophosphamide
Chlorambucil
MMICC
Methylmelamines & Ethylenimines
Altretamine
Thiotepa
Alkyl sulfonates
Busulfan
-SULFAN
Nitrosureas
Carmustine
Streptozocin
Polifeprosan 20
Hydration and mesna therapy are recommended for
Cyclophosphamide and ifosfamide
A nitrosureas that can cause pulmonary fibrosis
Carmustine
Ifosfamide adverse effect
encephalopathy
Polifeprosan/carmustine can induce
seizures
Monitoring parameters for Alkylating agents
Pulmonary fxn, chest x-ray
Renal & hepatic
CBC w/ diff & lytes
urinalysis (for RBC)
Bleeding
Infection
N/V
Antimetabolites
Folic acid antagonists
Pyrimidine analogs
Purine analogs
Folic acid antagonists
Pemitrexed
Methotrexate
Pyrimidine analogs
CytaraBINE
CapeCITABINE (Xeloda)
AzaCITIDINE
GemCITABINE
DeCITABINE
5-FU
CCAGeD...FU!
Purine analogs
Clofarabine
MercaptoPURINE
ThioGUANINE
Pentostatin
Cladribine
Fludarabine
To reduce damage to the mucosal lining in your mouth, you may be asked to chew ice if you are receiving
5-FU
If you have pain, swelling, or tingling in your palms or soles of your feet, you are probably taking what drug?
5-FU
Hand foot syndrome
You may have trouble urinating if you are on
clofarabine
a purine analog
What two injections should a patient receiving if they are on pemetrexed
Folic acid and vitamin B12
3 chemo agents from the antimetabolite class that may cause neurotoxicity
cytarbine
fludarabine
methotrexate
one from each group!
Flu like symptoms and hemolytic uremic syndrome from a pyrimidine analog
gemcitabine
Conjunctivitis is an ADR from
cytarabine
What chemo agent may cause tumor lysis syndrome, SIRS, or capillary leak?
clofarabine
Opportunistic infections are very common with what two antimetabolites?
Cladribine
Fludarabine
Purine analogs
This antimetabolite should inclue INR in the monitoring parameters
capecitabine (xeloda)
This antimetabolie should include diarrhea, janundice, and hepatomegaly in the monitoring parameters
Mercaptopurine
Clofarabine sounds pretty bad with the SIRS and all. What are three things that each patient on this should get?
Continuous IV fluids
Allopurinol
Corticosteroids
What two things should a pt with pemetrexed get?
Plasma homocysteine
Dexamethasone
Antitumor antibiotics
Anthracyclines
Alkylting-LIKE
Chromomycin
Bleomycin
Change of urine color or whites of eyes to a bluish-green or orangish-red are d/t
anthracyclines
Cardiac toxicity
Anthracyclines
Anthracyclines have limits on _______ lifetime dosing
CUMULATIVE
Are anthracyclines vesicants?
yep
Can anthracyclines cause any kind of secondary leukemia?
Acute myelogenous leukemia (AML)
yes....name it
Pulmonary fibrosis and intersitial pneumonitis is common with what antitumor ATB?
Bleomycin
Anthracycline dosing is adjusted based on elevated
TOTAL bilirubin
and, therefore, adjust w/ hepatic impairment
Anthracyclines
Doxorubicin
Daunorubicin
Epirubicin
Idarubicin
Valrubicin
Mitoxantrone
Most end in rubicin
Alkylating-lik
Mitomycin
Chromomycin
Dactinomycin
Bleomycin is _______ excreted
renally
Hormones and antagonists
Adrencorticoids
Progestins
Estrogens
Antiestrogen
Aromatase inhibitors
Androgens
Antiandrognes
LHRH agonists
GNRH agonst
Adrenocorticoids
Aminoglutethimide
Progestins
Megestrol acetate (Megace)
Medroxyprogesterone
Estrogens
Ethinyl estradiol
Anti-estrogen
Tamoxifen
Fulvestrant
Toremifene
Aromatase inhibitors
Exemestane
Anastrozole
Letrozole
Androgens
Testosterone
Fluoxymesterone
Anti-androgens
Flutamide
Vicalutamide
Nilutamide
LHRH agonsits
Triptorelin
Leuprolide
Goserelin
GNRH agonist
Abarelix
hormones and pregnancy
NO
Hormones may cause weight _____
GAIN
Leg swelling or tenderness may be signs of what
DVT
Transisent muscle or bone pain
problems urinating
spinal cord compression
LHRH agonsits
Abarelix's BLACK BOX WARNING:
Hypotension and syncope
Endometrial cancer may be a ADE for
tamoxifen
Exemestance should be taken with what regard to food?
after meals
Bone loss
LHRH
aromatase inhibitors
The majority of hormone therapy is ______ available
oral
Contraindication for hormones
More than one type of hormone-dependent tumor
Plant alklaoids
taxanes
epipodophyllotoxins
camptothecins
vinca alkaloids
Taxanes
Docetaxel
Paclitaxel
Epipodophyllotoxins
Etoposide
Teniposide
Camptothecins
Irinotecan
Topotecan
Vinca alkaloids
Vincristine
Vinblastine
Vinorelbine
Prophylaxis for emesis
Pretreatment for anapylaxis or peripheral edema
taxanes
With irinotecan therpay, you should get an RX for what?
Loperamide and atropine
Neurotoxicity
vincristine
Syndrome of inappropriate ADH secretion
vinca alkaloids
Drug resistance for plant alkaloids
p-glycoprotein pumps
Topotecan needs dose adjustments for patients w/ a CrCl <=
40 ml/ml
Are vincas vesicants?
YES
Bilogic response modifiers and monoclonal antibodies
Immune therapies
Monoclonal antibodies
Immunie therapies
Aldesleukin
Interferon-alfa 2b
Levamisole
Monoclonal antibodies
----MAB
denileukin diftitox
Biologic responspe modifiers have a direct biological effect on
malignancies
Monoclonal antibodies bind to specific antigens and kill cells through....
activation of apoptosis
complement-mediated lysis
Monoclonal antibodies can cause infusion-related reactions such as
fever and chills
Monitoring for Bevacizumab
BP checked and protien in urine
Cetuximab
photosenstive
Tositumomab
check thyroid
Tumor lysis syndrome with what monoclonal antibody
rituximab
Adverse reactions of bevacizumab
bleeding, hemorrhage
HTN
proteinuria
skin rash
4
Cutaneous and sever infusion RXNS
intersitial lund disease
cetuximab
hypothyroidism (mab)
tositumomab
Monoclonal ATB should be premedicated with
APAP and diphenhydramine
Cetuximab and ibritumomab can cause
TROUBLE BREATHING
Platinum compounds
Cisplatin
Carboplatin
Oxaliplatin
Adverse effects of platinum
nephrotox
peripheral neurotox
myelosuppression
ototox
N/V
4 things
which platinum needs hydration therapy and premedication
CISplatin
Which plantin should be monitored for thrombocytopenia
CARBOplantin
Which platinum has unique neurotoxicities such as bronchial spams
oxaliplatin
Asparaginase MOA
removes asparagines from leukemic cells
Intradermal skin testing w/ asparaginase b/c...
sever anaphylatic rxns
Asparaginase SE
melosuppression
hyperuricemia
hyperglycemia
renal
Hydroxyurea SE
secondary leukemias
N/V/D/C
mucositis
***rare fatal hepatotox and pancreatitis
Imatinib
PHILADELPHIA CHROMOSOME
Imatinib ADR
hepatotox
FLUID RETENTION
neutropenia
Erlotinib
HER-1 receptor
EGFR
Highly to moderately emetogenic
Dexamethasone
5-HT3 antagonists
*consider aprepitant
Low to unlikely emetogenic
dexamethasone
phenothiazine
delayed CINV
metoclopramide
dexamethasone
What vaccines should chemo pts NOT get?
live and rotavirus
5-HT3 antagonists
dolasetron (Anzemet)
Granisetron (Kytril)
Ondansetron (Zofran)
Palonosetron (Aloxi)
Phenothiazines
Prochlorperazine (Compazine)
Chlorpromazine (Thorazine)
Promethazine (Phenergan)
Neurokinin-1 antagonist
Aprepitant (Emend)