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9 Cards in this Set
- Front
- Back
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mercaptopurine
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antitumor, purine analog
negative effector of glutamine PRPP amidotransferase |
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fluorouracil
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antitumor,pyrimidine analog
into RNA and inhibits maturation of rRNA and splicing FdUMP is inhibitor of thymidilate synthase |
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cytosine arabinoside
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anti-leukemia, cytidine analog
competes with dCTP and inhibits growing of DNA strand |
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methotrexate
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antitumor, folate analog
inhibits dihydrofolate reductase causing decrease in tetrahydrofolate and thus thymidine and purines |
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azaserine and DON
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glutamine antagonists
reduced syn. of purines, GMP from IMP, cytosolic carbomyl phosphate, CTP from UTP and NAD |
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hydroxyurea
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not a nucleotide analog
inhibition of ribonucleotide reductase-inhibits DNA but not RNA synthesis |
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tiazofurin
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not a nucleotide analog
inhibits IMP dehydrogenase-no GTP |
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acyclovir
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purine base with sugar analog
anti herpes triphosphate form is substrate for the DNA polymerase-terminates DNA chain |
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AZT
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anti HIV, thymidine analog
inhibits DNA polymerase-RNA dependent |
