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33 Cards in this Set

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5-FU
Converted to 5-FdUMP, then inhibits thymidylate synthase
-Myelosuppression
-Same effect as MTX
Fludarabine
Can't be degrad by ADA, so accumulates and is toxic like adenosine
-Myelosuppressio
Cladiribine
2-chlorodeoxyadenosine. Can't be degrad'd by ADA > accumulates
-Hairy cell leukemia
-Myelosuppression
Cytarabidine
araC. Inhibs DNA synth
-Myelosuppression & mucositis
Etoposide
Inhibs TOPO>ds breaks
-11q23 translocations > MDS
-
Irinotecan
Inhibs TOPO > ds breaks
Doxorubicin
Intercalates into DNA & creates ROS> breaks
-Dose-dependent cardiotox > DCM
Daunorubicin
Intercalates into DNA & creates ROS> breaks
-Dose-dependent cardiotox > DCM
Dactinomycin
Binds dsDNA > blocks RNApol progression
-Childhood tumors
-Myelosuppression
Bleomycin
Intercalates > forms ROS > DNA damage
-Pulm fibrosis
Methotrexate
Inhibs DHFR, preventing methyl THF regeneration for thymidylate synthase
-Myelosuppression
-Luekovorin rescue
-Fatty change in liver>cirrhosis
Cyclophosphamide
Alkylating agent > crosslinking of DNA. Needs activation by liver
-Hemorrhagic cystitis
-Myelosuppression
Cisplatin
Crosslinks DNA w/o alkylation
-Nephrotox
-Ototox
-Periph neuropathy
Carboplatin
Crosslinks DNA w/o alkylation
-Nephrotox
-Ototox
-Periph neuropathy
Busulfan
Akylating agent > crosslinks dsDNA
-Pulm fibrosis
-Myelosuppression
Carmustine
Alkylating agent > dsDNA crosslinks. Can cross BBB
-CNS tox
-Myelosuppression
Hydroxyurea
Inhibs ribonucleotide reductase, preventing NTP > dNTP conversion
-Myelosuppression
-Used for sickle cell, thal to increase HbF
6-mercaptopurine
Activated HGPRTase and then inhibs PRPP and IMP>GMP
-Metab'd by xanthine oxidase, so incr efficacy & tox w/allopurinol
-Myelosuppression
Cell cycle-specific antineoplastics
Antimetabolites: MTX, 5-FU, 6-MP, AraC
Etoposide/irinotecan
Bleomycin
Vinca alkaloids/taxols
Rituximab
Anti-CD20 mAb
Trastazumab
Herceptin. anti-HER2/Neu mAb
-Breast CA
Tamoxifen
SERM. Inhibs at breast, stims at bone and endometrium
-Risk of endometrial CA
Raloxifene
SERM. Inhibs estrogen receptor at breast and endometrium
Bevacizumab
anti-VEGF
-Hypercoa
Cetuximab
anti-EGFR mAb
Vinblastine
Vinca alkaloid inhibs microtubule prolif
Vincristine
Vinca alkaloid inhibs microtubule prolif
-Periph neuropathy
Azacytidine
Inhibs DNA methyltransferase > unsilences genes
-Myelosuppression
Azathioprine
Converted to 6-MP, then by HGPRTase to active form that inhibs IMP>GMP and PRPP transferase
-Used for immunosuppression
-Myelosuppression
Mycophenalate mofetil
Inhibs IMP>GMP for immunosuppression
Asparginase
Degrades asparagine, preventing growth of cells that can't make their own
-Hypersensitiviity rxn
ATRA
Forces PML-RAR fusion to drive cell differentiation
-DIC
-Vitamin A tox
Paclitaxel
Prevents microtubule depolymeraization
-Myelosuppression