Characteristics Of Haart Drugs

Front 1

Abacavir

ABC

Back 1

Alcohol increases abacavir levels 41%

fever, rash,nausea, vomiting,malaise fatigue,loss of appetite,respiratory
symptoms

Front 2

Didanosine
(ddI)

Back 2

Levels decrease 55%;Take 1/2 hour before or 2 hours after meal

Pancreatitis; peripheral neuropathy; nausea; diarrhea Lactic acidosis with
hepatic steatosis

Front 3

Emtricitabine
(FTC)

Back 3

Take without regard to meals

Minimal toxicity;lactic acidosis with
hepatic steatosis(rare but potentially
life-threatening toxicity with using
of NRTIs.)

Front 4

Lamivudine
(3TC)

Back 4

Take without regard to meals

Minimal toxicity; lactic acidosis with hepatic steatosis rare but potentially
life-threatening toxicity with using
of NRTIs.

Front 5

Stavudine
(d4T)

Back 5

Take without regard to meals

Peripheral neuropathy;Lipodystrophy Rapidly progressive ascending neuromuscular weakness (rare)Pancreatitis;Lactic acidosis with hepatic steatosis

Front 6

Tenofovir Disoproxil Fumarate

Back 6

Take without regard to meals

Asthenia, headache,diarrhea, nausea, vomiting, and flatulence; lactic acidosis with hepatic steatosis

Front 7

Zalcitabine
(ddC)

Back 7

Take without regard to meals

Peripheral neuropathy;Stomatitis; Lactic acidosis with hepatic steatosis (rare but potentially lifethreatening
toxicity with using of NRTIs); Pancreatitis

Front 8

Zidovudine
(AZT,ZDV)

Back 8

Take without regard to meals

Bone marrow suppression:anemia or neutropenia;gastrointestinal intolerance,headache,insomnia,asthenia;Lactic acidosis with hepatic steatosis

Front 9

Delavirdine

Back 9

Take without regard to meals

Rash;Increased transaminaselevels; Headaches

Front 10

Efavirenz

Back 10

High-fat/highcaloric meals increase peak plasma concentrations of capsules by 39% and tablets by 79%; take on an empty stomach

Rash;Central nervous system symptoms; Increased transaminase levels;False-positive cannabinoid test;Teratogenic in monkeys

Front 11

Nevirapine

Back 11

Take without
regard to meals

Rash*;Symptomatic hepatitis,including
hepatic necrosis, have been reported

Front 12

Amprenavir

Back 12

High-fat meal decreases blood concentration curve 21%; can be taken with or without food, but high fat meal
should be avoided.

GI intolerance, nausea, vomiting, diarrhea;Rash;Oral paresthesias; Transaminase elevation;Hyperglycemia; Fat redistribution and lipid abnormalities;Possible increased bleeding episodes in patients with
hemophilia

Front 13

Atazanavir

Back 13

Administration with food increases bioavailability. Take with food

Indirect hyperbilirubinemia Prolong PR interval asymptomatic 1st degree AV block Use with caution in patients with
underlying condition defects or
on concomitant medications that
can cause PR prolongation;Hyperglycemia
;Fat maldistribution;Possible increased bleeding episodes in patients with hemophilia

Front 14

Fosamprenavir
(f-APV)

Back 14

No significant change in amprenavir pharmacokinetics in fed or fasting state

Skin rash (19%);Diarrhea, nausea, vomiting,Headache,Transaminase elevation,Hyperglycemia,Fat maldistribution and lipid abnormalitiesPossible increased bleeding episodes in patients with hemophilia

Front 15

Indinavir

Back 15

Levels decrease77% with food intake.
Take 1 hour before or 2 hours after
meals; may take with skim milk or
low-fat meal

Nephrolithiasis,GI intolerance, nausea
Increased indirect bilirubinemia, Headache, asthenia,blurred vision, dizziness, rash,metallic taste, thrombocytopenia,alopecia, and hemolytic anemia,Hyperglycemia Fat redistribution and lipid abnormalities Possible increased bleeding episodes in patients with hemophilia