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15 Cards in this Set

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Abacavir

ABC
Alcohol increases abacavir levels 41%

fever, rash,nausea, vomiting,malaise fatigue,loss of appetite,respiratory
symptoms
Didanosine
(ddI)
Levels decrease 55%;Take 1/2 hour before or 2 hours after meal

Pancreatitis; peripheral neuropathy; nausea; diarrhea Lactic acidosis with
hepatic steatosis
Emtricitabine
(FTC)
Take without regard to meals

Minimal toxicity;lactic acidosis with
hepatic steatosis(rare but potentially
life-threatening toxicity with using
of NRTIs.)
Lamivudine
(3TC)
Take without regard to meals

Minimal toxicity; lactic acidosis with hepatic steatosis rare but potentially
life-threatening toxicity with using
of NRTIs.
Stavudine
(d4T)
Take without regard to meals

Peripheral neuropathy;Lipodystrophy Rapidly progressive ascending neuromuscular weakness (rare)Pancreatitis;Lactic acidosis with hepatic steatosis
Tenofovir Disoproxil Fumarate
Take without regard to meals

Asthenia, headache,diarrhea, nausea, vomiting, and flatulence; lactic acidosis with hepatic steatosis
Zalcitabine
(ddC)
Take without regard to meals

Peripheral neuropathy;Stomatitis; Lactic acidosis with hepatic steatosis (rare but potentially lifethreatening
toxicity with using of NRTIs); Pancreatitis
Zidovudine
(AZT,ZDV)
Take without regard to meals

Bone marrow suppression:anemia or neutropenia;gastrointestinal intolerance,headache,insomnia,asthenia;Lactic acidosis with hepatic steatosis
Delavirdine
Take without regard to meals

Rash;Increased transaminaselevels; Headaches
Efavirenz
High-fat/highcaloric meals increase peak plasma concentrations of capsules by 39% and tablets by 79%; take on an empty stomach

Rash;Central nervous system symptoms; Increased transaminase levels;False-positive cannabinoid test;Teratogenic in monkeys
Nevirapine
Take without
regard to meals

Rash*;Symptomatic hepatitis,including
hepatic necrosis, have been reported
Amprenavir
High-fat meal decreases blood concentration curve 21%; can be taken with or without food, but high fat meal
should be avoided.

GI intolerance, nausea, vomiting, diarrhea;Rash;Oral paresthesias; Transaminase elevation;Hyperglycemia; Fat redistribution and lipid abnormalities;Possible increased bleeding episodes in patients with
hemophilia
Atazanavir
Administration with food increases bioavailability. Take with food

Indirect hyperbilirubinemia Prolong PR interval asymptomatic 1st degree AV block Use with caution in patients with
underlying condition defects or
on concomitant medications that
can cause PR prolongation;Hyperglycemia
;Fat maldistribution;Possible increased bleeding episodes in patients with hemophilia
Fosamprenavir
(f-APV)
No significant change in amprenavir pharmacokinetics in fed or fasting state

Skin rash (19%);Diarrhea, nausea, vomiting,Headache,Transaminase elevation,Hyperglycemia,Fat maldistribution and lipid abnormalitiesPossible increased bleeding episodes in patients with hemophilia
Indinavir
Levels decrease77% with food intake.
Take 1 hour before or 2 hours after
meals; may take with skim milk or
low-fat meal

Nephrolithiasis,GI intolerance, nausea
Increased indirect bilirubinemia, Headache, asthenia,blurred vision, dizziness, rash,metallic taste, thrombocytopenia,alopecia, and hemolytic anemia,Hyperglycemia Fat redistribution and lipid abnormalities Possible increased bleeding episodes in patients with hemophilia