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105 Cards in this Set

  • Front
  • Back

Antibody

protective protein produced by B lymphocytes in response to the presence of a foreign substance called and antigen


*also known as immunoglobulins (IGS)

antigen

substance, recognized as harmful to the host, that stimulates formation of antibodies in an immunocompetent individual

bile pigment

substance derived from the breakdown of hemoglobin and excreted by the liver


* interference w/the excretion of bile may lead to jaundice

cytokine

chemical substance produced by certain cells that initiates, inhibits, increases, or decreases activity in other cells


*important chemical communicators in the immune response

immunocompetent

ability to develop an immune response or recognize antigens and respond to them

natural killer (NK) cells

specialized lymphocytes that kill abnormal cells by releasing chemicals that destroy the cell membrane, causing its intercellular fluids to leak out.


* NK cells destroy virally infected cells and tumor cells.

3 solid components of blood

erythrocytes (red blood cells)


leukocytes (white blood cells)


thrombocytes (platelets)

blood

body tissue composed of cells suspended in a liquid medium called plasma

hematopoiesis


hemopoiesis

development of blood cells to their mature form

blastic (embryonic)

stem cells in the bone marrow give rise to these cell forms of all blood cell types.

erythrocytes

* Transport O2 and CO2


* most numerous of the circulating blood cells

hemoglobin

iron-containing compound gives erythrocytes their red color.


* shaped like biconcave disks


*live 120 days then rupture

where blood cells are formed

bone marrow of the skull, ribs, sternum, vertebrae, pelvis, and ends of the long bones of the arms and legs.

leukocytes

protect the body against invasion by pathogens and foreign substances, remove debris from injured tissue, and aid in the healing process.


*crucial to the body's defense against disease

two classifications of leukocytes

granulocytes


agranulocytes

3 types of granulocytes

neutrophils


eosinophils


basophils

neutrophils or polymorphonuclear leukocytes (PMNs)

stain pale lilac color


* do not show a marked affinity for either an acid dye (red) or alkaline (basic) dye (dark purple)


* responsible for ingesting & destroying bacteria and other foreign particles


*first to appear at site of injury or infection

eosinophils

contain granules that stain red due to their affinity for the red acid dye eosin


* main function is detoxification


*numerous during allergic reactions

basophils

granules that stain dark purple due to affinity for the purple alkaline (basic) dye


*main function is to release histamines and heparin at sites of injury

Histamine

initiate the inflammatory process by increasing blood flow.

heparin

an anticoagulant, acts to prevent blood from clotting at the injury site.

Agranulocytes (MNLs)


Mononuclear leukocytes

arise in the bone marrow from stem cells but mature in lymph tissues.


*play an integral part in the specific immune system


*typically have nuclei that do not form lobes


*Monocytes and lymphocytes


monocytes

mildly phagocytic when found within blood vessels.


*remain in vascular channels only a short time


*when they exit, called macrophages

lymphocytes

include B cells, T cells, and Natural Killer (NK) cells.


*learn to to recognize & destroy potential threats to the well-being of the individual

Platelets (thrombocytes)

the smallest formed elements found in blood.


*not true cells, only cell fragments


*initiate blood clotting when they encounter damaged vessel walls that have been injured or traumatized

hemostasis

control of bleeding


*complex series of interdependent reactions.


*become sticky initially and aggregate at the injury site to form a barrier to control blood loss

thromboplastin

substance that initiates clot formation


*released by platelets

fibrinogen

a soluble blood protein


*final step of coagulation


*becomes insoluble and forms fibrin strands that act as a net, entrapping blood cells


thrombus (blood clot)

jellylike mass of blood cells and fibrin

plasma

liquid portion of blood in which blood cells are suspended.


*appears as thin, almost colorless fluid when blood cells are removed


*composed of 92% water


*contains plasma proteins

plasma proteins

albumin, globulins, and fibrinogen

blood serum

product of blood plasma

serum

fibrinogen and clotting elements removed from plasma

lymph

fluid in lymph system in which lymphocytes and monocytes are suspended

lymph system

consists of fluid called lymph


*a network of transporting vessels called lymph vessels


*other structures including nodes, spleen, thymus, and tonsils

functions of the lymph system

1. Maintain fluid balance of the body by draining interstitial fluid from tissue spaces and returning it to the blood.


2. Transporting lipids away from the digestive organs for use by body tissues.


3. Filtering/removing unwanted or infectious products in lymph nodes.

interstitial fluid (tissue fluid)

small amount of plasma that seeps from blood capillaries


*resembles plasma, but contains less protein


*carries needed products to tissue cells while removing their waste.

lymph capillaries

closed ended microscopic vessels become lymph.

lymph nodes

macrophages phagocytize bacteria and other harmful material while T cells and B cells exert their protective influence.


right lymphatic duct

formed by the lymph vessels from the right chest and arm joint.


*drains into the right subclavian vein

right subclavian vein

a major vessel in the cardiovascular system

thoracic duct

receives lymph from all other areas of the body


and drains into the left subclavian veing

left subclavian vein

receives products of lymph from the thoracic duct

spleen

resembles a lymph node because it acts as a filter by removing cellular debris, bacteria, parasites, and other infectious agents.


*also destroys old RBCs and serves as a repository for healthy blood cells.

thymus

located in the upper part of the chest (mediastinum)


*controls the immune system by transforming certain lymphocytes into T cells to function in the immune system

tonsils

masses of lymphatic tissue located in the pharynx.


*act as filters to protect upper respiratory structures from invasion by pathogens.

humoral immunity

component of the specific immune system that protects primarily against extracellular antigens like bacteria and viruses

plassma cells

clones cells of B cells that produce highly specific proteins called antibodies

antigen-antibody complex

when an antibody encounters its matching antigen and attaches to it

cellular immunity

component of the specific immune system that protects primarily against intracellular antigens, such as viruses and cancer cells.

aden/o

gland

agglutin/o

clumping, gluing

bas/o

base (alkaline, opposite of acid)

blast/o

embryonic cell

chrom/o

color

eosin/o

dawn (rose-colored)

erythr/o

red

granul/o

granule

hemo/


hemat/o

blood

immun/o

immune, immunity, safe

kary/o


nucle/o

nucleus

leuk/o

white

lymphaden/o

lymph gland (node)

lymph/o

lymph

lymphangi/o

lymph vessel

morph/o

form, shape, structure

myel/o

bone marrow, structure

neutr/o

neutral, neither

phag/o

swallowing, eating

plas/o

formation, growth

poikil/o

varied, irregular (what a cell looks like)

reticul/o

net, mesh

ser/o

serum

sider/o

iron

splen/o

spleen

thromb/o

blood clot

thym/o

thymus gland

xen/o

foreign, strange

-blast

embryonic cell

-emia

blood condition

-globin

protein

-graft

transplantation

-osis

abnormal condition; increase (used primarily with blood cells)

-penia

decrease, deficiency

-phil

attraction for

-phoresis

carrying, transmission

-phylaxis

protection

-poiesis

formation, production

-stasis

standing still

a-

without, not

allo-

other, differing from the normal

aniso-

unequal, dissimilar

iso-

same, equal

macro-

large

micro-

small

mono-

one

poly-

many, much

acquired immunity

most complicated type of body resistance

resistance

numerous body defenses work together to protect against disease.

innate

forms of resistance present at birth are innate

macrophages

monocytes that entered tissue spaces


* in this form, they consume large numbers of pathogens

2 types of lymphocytes

B cells and T cells are the active cells of the adaptive immune response.

Helper T cell

essential to the proper functioning of both humoral and cellular immunity

cytotoxic T cell

cell that actually destroys the invading antigen

suppressor T cell

monitors the progression of infection