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17 Cards in this Set
- Front
- Back
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Psyllium |
Metamucil Bulk Producing Laxative |
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Calcium Polycarbophil |
Fibercon Bulk Producing Laxative |
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Methylcellulose |
Citrucel Bulk Producing Laxative |
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Bulk Producing Laxatives |
Forms gel like matrix in the stool ADR: bowel obstruction if strictures present, choking if powdered form not taken with enough liquid DOC in pregnancy *take 2 hours before or after drugs |
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Docusate |
Colace Emollient (also mineral oil) *advise not to take > 7 days w/o consulting physician |
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Stimulants and irritants |
MOA: reduce water and electrolyte absorption by stimulating colonic neurons and irritating the mucosal lining Avoid use in stomach pain, N/V, or sudden change in bowel movements lasting > 2 weeks ADR: electrolyte imbalance with overdose Onset: 10 hours |
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Senna |
Ex-Lax Stimulant Laxative |
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Bisacodyl |
Dulcolax Stimulant Laxative Rectal formulation - onset of action 10 min |
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Lubiprostone |
Amitiza MOA: activated Cl channels in the gut - causes increased fluid in the gut and peristalsis ADR: nausea, diarrhea, headache Dosing 24 mcg twice daily with food |
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Linaclotide |
Linzess MOA: agonist of guanylate cyclase C, which increases chloride and bicarb secretion into the intestines which decreases transit time Approved for chronic idiopathic constipation and IBS ADR: diarrhea, abdominal distension |
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Osmotic Laxatives |
Magnesium Salts Lactulose Sorbitol Onset: 4 hours ADR: electrolyte imbalance, dehydration |
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Sodium Phosphate |
Fleet Enema Warning: do not use in renal disease, CHF, hypocalcemia or hyperphosphatemia Onset: 5 minutes |
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Polyethylene Glycol |
Golytely, Miralax, Carbowax Nonabsorbable solutions For bowel prep: 8 oz q10min until 2L gone Onset of action: 4 hours |
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Methylnaltrexone |
Relistor MOA: blocks opioid receptors in the gut to reduce the constipating effects of opioids Warning: GI perforation *only for patients who have failed DSS + laxative *stay close to the toilet after injection SC injection administered qod |
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Alvimopan |
Entereg MOA: blocks opioid receptors in the gut to reduce the constipating effects of opioids *must be hospitalized to receive this drug - one dose administered before surgery, then bid up to 7 days BBW: MI risk - REMS CI: therapeutic opioid doses > 7 days prior to use Limited to post-surgical patients to decrease risk of post-op ileum |
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Naloxegol |
Movantik C-II PAMORA - peripherally acting mu-opioid receptor antagonist for the treatment of opioid induced constipation in adults with chronic non cancer pain |
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Diphenoxylate + Atropine |
Lomotil (2.5 mg / 0.025 mg) - 5 mg up to QID Diphenoxylate MOA: inhibits excessive GI motility and GI propulsion ADR: anticholinergic |
