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14 Cards in this Set

  • Front
  • Back
the strength with which a ligand interacts with a binding site. It is represented quantitatively by the affinity constant Ka.
Equilibrium dialysis
an experimental technique that can be used to determine the affinity of an antibody for antigen and its valency
the strength of antigen-antibody binding when multiple epitopes on an antigen interact with multiple binding sites of an antibody
ability of a particular antibody or T-cell receptor to react with two or more antigens that possess a common epitope
ABO blood-group antigens
antigenic determinants of the blood-group system defined by the agglutination of red blood cells exposed to anti-A and anti-B antibodies
an antibody that aggregates a soluble antigen, forming a macromolecular complex that yields a visible precipitate
Equivalence zone
the point or region of a gel in which the ratio of antigen to antibody is optimal for the production of an antigen-antibody precipitate
Radical immunodiffusion
a method for determining the relative concentration of an antigen. The antigen sample is placed in a well and allowed to diffuse into agar containing a suitable dilution of an antiserum. The area of the precipitin ring that forms around the well in the region of equivalence is proportional to the concentration of antigen.
Double immunodiffusion
a type of precipitation in gel analysis in which both antigens and antibody diffuse radially from wells toward each other, thereby establishing a concentration gradient. As equivalence is reached, a visible line of precipitation, a precipitin line, forms.
a technique in which an antigen mixture is first separated into its component parts by electrophoresis and then tested by double immunodiffusion
Rocket electrophoresis
the electrophoresis of a sample of negatively charged antigen in a gel that contains antibody. The precipitate formed between antigen and antibody has the shape of a rocket, whose height is proportional to the concentration of antigen in the sample.
the aggregation or clumping of particles or cells
a substance capable of mediating the clumping of cells or particles. In particular, a hemagglutinin causes clumping of RBC
Prozone effect
the apparent decrease in an antigen-antibody reaction sometimes observed as the concentration of antigen or antibody is increased