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11 Cards in this Set
- Front
- Back
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What is Rheumatoid arthritis?
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Systemic inflammatory disease of connective tissue, affecting women more than men and incidence increases with age.
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What is the cause of RA?
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80% have Rheumatoid factor antibody directed against synovial membrane (IgG/M) in blood.
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What are contributing factors of RA?
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Genetic disposition, virus, HLA-DR4.
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What is the pathogenesis of RA?
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RF in blood, synovial fluid, and synovial membrane. It forms immune complexes which activate complement system->inflammation
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What is Pannus?
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Destructive vascular granulation tissue involves synovium
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What are the clinical manifestations of RA?
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Exacerbations and remissions.
Four or more of the following conditions must be presentto establish a diagnosis of rheumatoid arthritis: 1.Morning stiffness for at least 1 hour and presentfor at least 6 weeks 2.Simultaneous swelling of three or more joints forat least 6 weeks 3.Swelling of wrist, metacarpophalangeal, or proxi-mal interphalangeal joints for 6 or more weeks 4.Symmetric joint swelling for 6 or more weeks 5.Rheumatoid nodules 6.Serum rheumatoid factor identified by a methodthat is positive in less than 5% of normal subjects 7.Radiographic changes typical of rheumatoid arthritison hand or wrist radiographs. |
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What is osteoarthrits?
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Degenerative joint disease (the most common form of chronic arthitis).
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What are the patho/characteristics of osteoarthritis?
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Loss of articular/joint cartilage and associated inflammation of the synovial membrane secondary to use/abuse of joint.
Increases with age. |
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What is the cause of osteoarthritis?
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Idiopathic; may be primary or secondary to injury.
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What is the manifestations of osteoarthritis?
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unilateral, asymmetric pain that tends to improve throughout the day. Crepitus. More common in hands in women, more common in knees and hips in men.
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What is crepitus?
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A grating sound or sensation produced by friction between bone and cartilage or the fractured parts of a bone.
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