Chapter 40 Upper Gastrointestinal System Drugs

Front 1

Stomach bacterium that causes peptic ulcer

Back 1

Helicobacter pylori

Front 2

drugs that neutralize or reduce the acidity of stomach and duodenal contents by combining with HCl and increasing the pH of the stomach acid.

Back 2

Antacids

Front 3

particularly important in the treatment of Helicobacter pylori infection in patients with active duodenal ulcers.

Back 3

Proton pump inhibitors

Front 4

believed to cause a type of chronic gastritis and some peptic and duodenal ulcers as well.

Back 4

H. pyloriare

Front 5

facilitate emptying of stomach contents into the small intestine and are used both as ulcer treatments and as antiemetics.

Back 5

GI stimulants

Front 6

What drug class has •Actions:

–Neutralize or reduce acidity of stomach and duodenal contents by combining with HCl and increasing the pH of the stomach acid

Back 6

Acid Neutralizers: Antacids

Front 7

Acid Neutralizers: Used in treatment of

Back 7

hyperacidity caused by: –Heartburn, acid indigestion, sour stomach, gastroesophageal reflux disease, peptic ulcer

Front 8

Calcium-containing antacids: Contraindicated in patients with

Back 8

renal calculi or hypercalcemia

Front 9

Acid Neutralizers: Antacids: Interactant drugs

Back 9

Digoxin, Tetracyclin, Corticosteroids, Salicylate, Quinidine

Front 10

What drug class has Actions:

–Inhibit the action of histamine at H2 receptor cells of the stomach, which then reduces the secretion of gastric acid

Back 10

Histamine H2 Antagonists

Front 11

Histamine H2 Antagonists Used in treatment of: –

Back 11

Heartburn, acid indigestion, sour stomach, GERD, gastric ulcer, gastric hypersecretory conditions

Front 12

Histamine H2 Antagonists Adverse reactions :

Back 12

Dizziness, somnolence, headache–
Confusion, hallucinations, diarrhea, and reversible impotence

Front 13

Histamine H2 Antagonists: Contraindications and Precautions

Back 13

cautiously in patients with renal or hepatic impairment and in severely ill, elderly, or debilitated patients: Used with caution during pregnancy and lactation

Front 14

Histamine H2 Antagonists Interactant drugs

Back 14

Antacids, Opioid analgesics, Oral anticoagulants, Digoxin

Front 15

What drug class has Action:

Suppress gastric acid secretion by inhibition of hydrogen-potassium adenosine triphosphatase enzyme system of the gastric parietal cells

Back 15

Proton Pump Inhibitors

Front 16

Proton Pump Inhibitors Used in treatment of:

Back 16

gastric and duodenal ulcers, GERD and erosive esophagitis, pathologic hypersecretory conditions

Front 17

Proton Pump Inhibitors Adverse reactions

Back 17

Headache, nausea, diarrhea, abdominal pain

Front 18

Proton Pump Inhibitors: Contraindications and Precautions

Back 18

Used cautiously in older adults and in patients with hepatic impairment : Contraindicated during pregnancy and lactation

Front 19

Proton Pump Inhibitors Interactant drugs

Back 19

Clarithromycin, Benzodiazepines, Digoxin, Oral anticoagulants, ampicillin, Sucralfate

Front 20

Reduces gastric motility and decreases the amount of acid secreted by the stomach

Back 20

Cholinergic blocking drugs

Front 21

Binds with protein molecules to form a viscous substance which buffers acid and protects the mucosal lining

Back 21

Pepsin inhibitor

Front 22

Reduces the risk of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in high risk patients

Back 22

Prostaglandin drug

Front 23

Gastrointestinal Stimulants Actions:

Back 23

Increase the motility of the upper GI tract without increasing the production of secretions

Front 24

Gastrointestinal Stimulants Used in treatment of

Back 24

GERD, gastric stasis

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Gastrointestinal Stimulants : Higher doses or prolonged administration:

Back 25

Produce central nervous system (CNS) symptoms

Front 26

Dexpanthenol administration: Causes

Back 26

itching, difficulty breathing, and urticaria