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21 Cards in this Set
- Front
- Back
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What are the three groups of cells (according to proliferative capacity?)
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Labile
Stable Permanent |
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How do stem cells retain their self-renewal capacity?
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Asymmetric replication
Stochastic differentiation |
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What their induced pluripotent stem cells?
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Generated by reprogramming adult diffrentiated cells
Different from ES cells generated through nuclear transfer techniques |
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What are embryonic stem cells?
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Pleuripotent
Used to generate knock-outs |
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What are somatic stem cells?
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Reside within special niche environments
Give rise to rapidly proliferating transient amplifying cells |
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What is transdifferentiation?
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When a cell differentiates into another type
Capacity to differentiate is called developmental plasticity Likely in vitro rather than in vivo |
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Where are the stem cells for (1) liver (2) brain (3) skin (4) small intenstine (5) muscle (6) cornea
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Liver - oval
brain - dentate gyrus skin - hair follicle buldge small intestine - crypt muscle - satellite cells cornea - limbus |
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What are the stages of the cell cycle? What happens during each stage?
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G1
S G2 M |
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Name a few growth factors.
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.
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What signalling mechanisms for cells exist for cell growth?
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.
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Name a few types of receptors and their signalling transduction pathways
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.
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Which organ shows the ability to regenerate?
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Liver
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What are the components of the ECM?
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Fibrous structural proteins
Adhesive glycoproteins Gel (of proteoglycans and hyaluronan |
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Discuss the main types of collagens, their distributions and associated genetic disorders.
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.
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How is collagen synthesized?
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.
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What is the structure of an elastic fibre?
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.
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What are the classes of cell adhesion proteins?
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Immunoglobulins
Cadherins Intergrins Selectins |
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What is the sequence of healing?
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.
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What are the mechanisms of angiogenesis? What are the two sources of cells for angiogenesis?
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.
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What are the steps in wound healing?
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.
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What is the pathogenesis of fibrosis?
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