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12 Cards in this Set
- Front
- Back
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Produced by G cells in antrum
Target cells - parietal cells and chief cells |
GASTRIN
Response -increase in HCI, intrinsic factor, and pepsinogen secretion |
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inhibited by :
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GASTRIN
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produced by D cell in the antrum
stimulated by acid in the duodenum |
somatostatin
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produced by K cell in the duodenum
Target cells - parietal cell of the stomach, and beta cells of the pancreas, Response- decrease in HCL and pepsin, increase in insulin release |
gastric inhibitory peptide
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produced by I cells of the duodenum and jejunum
Response - gallbladder contraction , relaxation of the sphincter of Oddi, increases pancreatic enzyme secretion , some increase in intestinal motility |
CCK
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produced by S cells of duodenum
secreation stimulated by fat, bile, pH <4, inhibited by gastrin |
Secretin
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produced by cells in gut and pancreas
Secretion stimulated by fat and acetylcholine, Response - increased intestinal secretion (water and electrolytes) and motility Inhibits gastrin release |
vasoactive intestinal peptide
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Secretion stimulated by: glucose,glucagon, CCK
Secretion inhibited by somatostatin and pancreatostatin Response - cellular glucose uptake; promotes protein synthesis |
insulin
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• Response – ↑ pancreatic HCO3− release, inhibits gastrin release (this is reversed in patients withgastrinoma), and inhibits HCl release
• High pancreatic duct output – ↑ HCO3−, ↓ Cl− • Slow pancreatic duct output – ↑ Cl−, ↓ HCO3− (carbonic anhydrase in duct exchanges HCO3− forCl−) |
Secretin |
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(gastrin-releasing peptide) – ↑ intestinal motor activity, ↑ pancreatic enzyme secretion, ↑gastric acid secretion
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Bombesin
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released from terminal ileum following a fatty meal → inhibits acid secretion andstomach contraction; inhibits gallbladder contraction and pancreatic secretion
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Peptide YY
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Bowel recovery
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• Small bowel 24 hours
• Stomach 48 hours • Large bowel 3–5 days |
