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22 Cards in this Set
- Front
- Back
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Most cases of warm autoimmune hemolytic anemia will be DAT positive with which of the following?
A) anti-IgG only B) anti-C3d only C) both anti-IgG and C3d D) none of the above |
c) both anti IgG and C3d
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2.
Cold hemagglutinin disease represents what percentage of autoimmune hemolytic anemia (AIHA) cases. A) 16 B) 70 C) 12 D) 25 |
a) 16
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3.
Persons diagnosed with pneumonia caused by Mycoplasma pneumoniae may produce a cold autoantibody with ____________ specificity. A) anti-H B) anti-i C) anti-I D) anti-P |
c) anti I
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4.
Which of the following is a characteristic red cell morphology seen on a peripheral blood smear from a patient with warm autoimmune hemolytic anemia? A) stomatocytes B) tear drop cells C) microspherocytes D) target cells |
c) microspherocytes
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5.
Immune hemolytic anemia is defined as: A) increased red blood cell (RBC) destruction caused by radiation exposure B) shortened RBC survival caused by defective DNA synthesis C) shortened RBC survival mediated thru humoral antibody production D) increased RBC destruction caused by enzyme defects |
c) shortened RBC survival mediated thru humoral antibody production
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6.
Which cells contain the most i antigen? A) lymphocytes B) cord blood C) adult red cells D) platelets : |
b) cord blood
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7.
Which drug-induced mechanism does not result in a hemolytic episode? A) immune complex formation B) drug adsorption C) membrane modification D) methyldopa-induced autoantibody |
c) membrane modification
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8.
All of the following are clinical manifestations of cold hemagglutinin disease (CHD) except: A) agglutination of red blood cells in skin capillaries B) pallor and cyanosis of the hands and feet C) hepatosplenomegaly D) Raynaud's phenomena |
c) hepatospenomegaly
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9.
In addition to methyldopa, what other drug can cause production of autoantibody? A) penicillin B) isoniazid C) ibuprofen D) tetracycline |
c) ibupropen
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10.
In which of the following, the DAT is reactive with anti-C3d only? A) drug adsorption mechanism B) warm autoimmune hemolytic anemia C) cold hemagglutinin disease D) membrane modification |
c) cold hemagglutnin disease
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11.
How can persons with cold hemagglutinin disease (CHD) avoid hemolytic episodes? A) have a splenectomy B) move to a warm climate C) corticosteroid therapy D) move to the North Pole |
b) move to a warmer climate
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12.
Which of the following factors distinguishes a cold autoantibody produced in a patient with infectious mononucleosis from that produced from pneumonia? A) a titer greater than 64 B) an IgM class of antibody C) a wide thermal range D) anti-i specificity |
d) anti i specificity
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13.
All of the following drugs have been known to form immune complexes except: A) penicillin B) quinidine C) streptomycin D) diphenhydramine |
a) penicillin
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14.
How might a technologist detect a patient with drug-induced hemolytic anemia? A) a positive rosette test B) a positive antibody screen C) a positive DAT D) an ABO discrepancy |
c) a positive DAT
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15.
What technique can be used to identify an alloantibody in the presence of a cold autoagglutinin? A) prewarming B) enzyme treatment C) chloroquine treatment D) polyethylene glycol |
a) pre warming
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16.
What is the most common drug associated with the drug-adsorption mechanism? A) erythromycin B) penicillin C) methyldopa D) insulin |
b) penicillin
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17.
What percentage of autoimmune hemolytic anemia (AIHA) cases are caused by warm reacting autoantibodies? A) 18% B) 70% C) 12% D) 25% |
b) 70%
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Why do clotted specimens yield positive DAT results with anti-C3 in the presence of a benign cold autoagglutinin?
A) Complement is inhibited due to calcium chelation. B) Complement can be activated in vivo. C) Complement can be activated in vitro. D) Complement is activated in the absence of fibrinogen. |
c) complement can be activated in vitro
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19.
Approximately what percentage of autoimmune hemolytic anemia (AIHA) cases are due to paroxysmal cold hemoglobinuria (PCH)? A) 70% B) 12% C) 2% D) 18% |
c) 2%
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20.
What is the recommended treatment for drug-induced hemolytic anemia caused by the immune complex mechanism? A) splenectomy B) immunosuppressive therapy C) cessation of drug administration D) transfusion |
c) cessation of drug administration
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21.
What is the most frequent antibody specificity in cold hemagglutinin disease (CHD)? A) anti-IH B) anti-i C) anti-I D) anti-P |
c) anti I
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22.
How can cold autoantibody intereference with ABO grouping be avoided? A) washing cells with normal saline cooled to 4°C B) washing cells with normal saline warmed to 37°C C) treating red cells with ficin prior to testing D) washing cells with normal saline (room temperature) |
b) washing cells with normal saline warmed to 37 C
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