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6 Cards in this Set

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Leukocytes (WBC)




1. Neutrophils: Phagocytic, most prominent, first to act against bacterial infection.


2. Eosinophils: Defend against parasites and allergens.


3. Basophils: Similar to MAST cells; act in allergic reactions.


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4. Monocytes: Phagocytic; mature into macrophages in tissue.


5. Lymphocytes:


- B Cells and T cells are involved in acquired immunity.


- Natural Killer (NK) cells destroy virus-infected and abnormal cells.

*Dendritic Cells:


- Found in the skin and other points of pathogen origin. Also involved in innate and activation of acquired immunity.

*Human Lymphatic System




- Primary lymphoid tissues are the thymus and bone marrow.




- Secondary lymphoid tissues are the spleen and lymph nodes and tonsils.




--> The spleen contains cells that monitor fight infectious microbes.


--> The lymph nodes contain phagocytes and lymphocytes.



*Formation of Neutrophil Extracellular Traps (NET's)




- Some neutrophils transform into extracellular fibers (NET's).



1. Nuclear envelope and granule membranes disintegrate and mix.


2. Pathogens get caught in NET fibers.


3. Antimicrobials degrade and kill pathogens.

*The Process of Inflammation


- Inflammation plays an important role in fighting infection.


1. Tissue macrophages intiate phagocytosis and secrete cytokines.


2. Capillary walls dilate, causing edema, heat, redness and pain.


3. More phagocytes come to site of injury.


4. Fibrin wall forms around injury preventing the spread of the pathogens.

*Natural Killer (NK) Cell Recognition




- When an NK cell recognizes a cell as "nonself" it releases cytotoxic perforins and granzymes.