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15 Cards in this Set

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  • Back
glycolysis
bd of carbs to resynth ATP

pyruvate

end result of glycolysis

2 possible directions for pyruvate:


1 convert to lactate- ATP resynth faster, limited duration




2 shuttled into mitochondria- kreb cycle, ATP rate slower, longer duration(if low intensity)




*depends on energy demands


muscle acidosis


exercise induced decrease in pH


-direct effect on muscle excite contract-coupling

factors that effect lactate accumulation:




1 intensity


2 MF type


3 duration


4 initial glycogen levels



blood lactate concentration

lactate production and clearance
cori cycle

lactate transported in blood to liver and converted to glucose
glycolysis to kreb cycle


-pyruvate concerted to acetyl-CoA


-acetyl-CoA enters kreb for ATP resyth.


Allosteric (othersite) regulation


end product of reaction feeds back to regulate the turnover rate of key enzymes


* "endpoint"

allosteric inhibition

occurs when end product binds to regulatory enzyme


-decreases turnover rate and product function

allosteric activation

binds with enzyme


- increases its turnover




* "activator"


lactate threshold

blood lactate begins an abrupt increase above baseline concentration

onset of blood lactate accumulation

2nd increase in rate of lactate accumulation


- occurs with higher intensity of exercise

Oxidative system
"aerobic" system

-prim source of ATP @rest, low intensity

oxidative ATP production

-70% fats, 30% carbs


- protein only during long term starvation, long bouts of exercise (>90 min)


- as intensity increases, there is shift from fats>>carbs