Chapter 18 Adrenergic Antagonists

Front 1

Therapeutic applications of Alpha blockade

Back 1

-Essential Hypertension - lowers blood pressure by causing vasodilation
-Reversal of Toxicity from alpha1 agonists
-Benign Prostatic hyperplasia- reduced contraction of smooth muscle in the bladder reduces the urge to void constantly
-Pheochromocytoma- suppress hypertension
-Raynaud's disease-can prevent vasoconstriction that makes you feel cold

Front 2

Adverse effects of Alpha blockade

Back 2

-Orthostatic hypotension
-Reflex Tachycardia- trying to restore normal blood pressure
-Nasal congestion- dilate the blood vessels in the nose and produces nasal congestion
-Inhibition of Ejaculation due to alpha1 receptor block

Front 3

Therapeutic use of Prazosin

Back 3

- treat hypertension
-Not approved but could be used for BPH (prostate enlargement)

Front 4

Adverse effects of Prazosin

Back 4

-orthostatic hypotension
-reflex tachycardia
-inhibition of ejaculation
-nasal congestion

Front 5

What should patients be educated about with adverse effects of alpha blockade

Back 5

S/S of orthostatic hypotension-dizziness, lightheadedness, and should be advised to sit or lie down if these occur
--also tell them that it can be minimized by avoiding abrupt movements

Front 6

Other Alpha blockers

Back 6

Dozazosin
Tamsulosin
Alfuzosin
Silodosin
Phentolamine

Front 7

Therapeutic Applications of Beta Blockade

Back 7

-Angina Pectoris- decrease cardiac work
-Hypertension-?? not really used for this anymore
-Cardiac Dysrhythmias-decrease the rate of sinus nodal discharge and suppress conduction of atrial impulses through the AV node
-Myocardial infarction
-reduction of perioperative mortality
-Heart failure- standard care
-Hyperthyroidism
-Mirgaine Prophylaxis
-Stage fright
-Pheochromocytoma
-Glaucoma

Front 8

Adverse effects of Beta1 Blockade

Back 8

-Bradycardia
-Reduced Cardiac Output
-Precipitation of Heart failure
-AV heart block
-Rebound Cardiac excitation

Front 9

Adverse effects of Beta2 Blockade

Back 9

-Bronchoconstriction
-Hypoglycemia from inhibition of glycogenolysis

Front 10

Propanolol therapeutic uses

Back 10

-Hypertension
-Angina Pectoris
-Cardiac dysrhythmias
-myocardial infarction


-prevention of migraine headache
-stage fright

Front 11

Adverse effects of Propranolol

Back 11

-Bradycardia
-AV heart block
-Heart failure
-Rebound cardiac excitation
-Bronchoconstriction
-Inhibition of glycogenolysis
-CNS effects- depression, insomnia, nightmares
-Effects in neonates

Front 12

Contraindications for propranolol use

Back 12

- Severe allergies (it works the opposite of epinephrine which is used to treat anyphlactic shock)
-Diabetes
-Cardiac, Respiratory and Psychiatric Disorders- can be exacerbated by propanolo

Front 13

Drug interactions of propanolol

Back 13

-Calcium channel blockers- can cause excessive cardiosuppression (increases effects)
-Insulin

Front 14

Metoproplol Therapeutic Uses

Back 14

-Hypertension (Main)
-angina pectoris
-heart failure
-myocardial infarction

Front 15

Adverse effects of metoproplol

Back 15

-bradycardia
-reduced cardiac output
-av heart block
-rebound cardiac excitation following abrupt withdrawal