Chapter 17, Drugs For The Tx Of Cns Disorders

Front 1

1. Psychosis

Back 1

Schizophrenia, extrapyramidal symptoms, loss of reality, etiology is unknown but may be a familiar pattern.

Front 2

Positive Symptoms of Psychoses

Back 2

Hallucinations, delusions, unwanted thoughts, agitation, distorted speech, disorganized behavior

Front 3

Negative Symptoms of Psychoses

Back 3

Apathy, unemotional, lacking goals, lack of pleasure, social withdrawal, abstract in thinking

Front 4

2. Affective Disorders

Back 4

depression as a result of biologic, (low levels of serotonin, NE, or dopamine) psychological, and social factors. bipolar depression

Front 5

3. Anxiety Disorders

Back 5

less severe than psychoses. anxiety, panic disorder, phobias, OCD

Front 6

Antipsychotic Agents

Back 6

Treats schizophrenia, delusional disorders

Front 7

First-Generation Antipsychotic Agents

Back 7

Treat the positive symptoms. Their MOA are dopamine antagoinsts.

Front 8

Second-Generation Antipsychotic Agents

Back 8

Treat the negative & positive symptoms. They are better tolerated. Their MOA is that they have action at more than one receptor which improves efficacy.

Front 9

First-Generation Pharmacologic Effects

Back 9

Antipsychotic & Antiemetic (used for nausea), used for hiccups, sedation

Front 10

Adverse Reactions of First-Generation

Back 10

sedation, tremors, orthostatic hypotension,

tachycardia, blurred vision, xerostomia, skin eruptions, constipation

Front 11

Second-Generation Pharmacologic Effects

Back 11

Used for bipolar depression. Less extrapyramidal effects, tachycardia, higher risk of diabetes & hyperglycemia, agranulocytosis, weight-gain

Front 12

----- Antidepressant Agents

Back 12

Used to treat depression, chronic pain, migraine headache. Improvement is at 2 weeks and up to 4-8 weeks

Front 13

Selective Serotonin Reuptake Inhibitors

(antidepressant agent)

Back 13

1st line of treatment for major depression, well tolerated.

Front 14

Adverse Reactions of SSRI

Back 14

weight loss, taste changes, xerostomia,

glossitis, sweating

Front 15

Drugs that are SSRI

Back 15

1. Fluoxetine (Prozac)

2. Sertraline (Zoloft)

3. Citalopram (Celexa)

4. Escitralopram (Lexapro)

Front 16

Serotonin-Norepinephrine Reuptake Inhibitors (antidepressant agent)

Back 16

also the 1st line of therapy used for depression. patients must be tapered off. Sweating, urinary retention, tachycardia

Front 17

Drugs that are SNRI

Back 17

1. Venlafaxine (Effexor)

2. Duloxetine (Cymbalta)

3. Desvenlafaxine (Pristiq)

Front 18

Tricyclic Antidepressants (antidepressant agent)

Back 18

They are the first ones that were out there. can take these for one month or longer.

Front 19

Adverse Reactions of Tricyclic

Back 19

sedation, anticholineric, xerostomia, blurred vision, constipation, tachycardia, arrhythmias

Front 20

MAOIs

Back 20

ability to inhibit monoamine oxidase, USED AS LAST DRUG OF CHOICE, side effects are weight gain & orthostatic hypotension

Front 21

Bupropion (Wellbutrin SR)

Back 21

dopamine-NE reuptake inhibitor, may cause seizures. USED ONLY FOR PATIENTS WHOSE DEPRESSION IS UNRESPONSIVE, side effects are constipation, sweating, nausea, xerostomia, tremors, & headache

Front 22

Trazadone (Desyrel)

Back 22

serotonin modulator antidepressant, also is prescribed at night for sleep, highly sedative

Front 23

----Treatment of Bipolar Depression

Back 23

Lithium: it's handled in the body like sodium so sodium levels are effected, some NSAIDS can decrease lithium clearance

Front 24

Side Effects of Lithium

Back 24

polyuria, hand tremors, thirst, slurred speech, nausea