• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/233

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

233 Cards in this Set

  • Front
  • Back
Mice infected with Nippostrongulus brasiliensis exhibit decreased production of IgE
False: IgE is increased
IL-4 decreases IgE production by B cells
False: IL-4 increases IgE production
The initial step in the process of mast cell degranulation is cross linking of Fc receptors.
TRUE
Antihistamines are effective for the treatment of type III hypersensitivity
False: Antihistamines are helpful in the type I hypersensitivities, which involves release of histamines by mast cell degranulation. Because type III hypersensitivity involves immune complex deposition, antihistamines are ineffective.
Most pollen allergens contain a single allergenic component.
False: Most allergens contain multiple allergenic components.
Babies can acquire IgE-mediated allergies by passive transfer of maternal antibodies.
False: Unlike IgG, IgE cannot pass through the placenta
Transfusion reaction are a manifestation of type II hypersensitivity
TRUE
"Mice injected intradermally with complete antibodies to the IgE Fc receptor (FcERI)
or with Fab fragments of such antibodies. Predict the response expected with each type of antibody." "The complete antibodies would crosslink FcE RI molecules on the membrane of mast cells
and basophiles, resulting in their activation and degranulation. The released mediators would
induce vasodilation, smooth muscle contraction, and a local wheal and flare reaction. Because the fab fragment is monovalent, it cannot crosslink FcERI molecules and thus cannot induce degranulation. However this type of antireceptor antibody could bind to FcERI and might thereby block binding of IgE to the receptors."
The response induced by complete anti-FceRI antibodies does not depend on allergen specific IgE and thus would be similar in allergic and nonallergic mice. Injection of Fab fragments of anti-FceRI might prevent allergic mice from reacting to an allergen if these fragments block binding of IgE to mast cells and basophiles.
Serum sickness can result when an individual is given a large dose of antiserum such as a mouse antitoxin to snake venom. How could you take advantage of recent technological advances to produce an antitoxin that would not produce serum sickness in patients who receive it? Engineer chimeric monoclonal antibodies to snake venom that contain mouse variable regions but human heavy and light chain constant regions.
Engineer chimeric monoclonal antibodies to snake venom that contain mouse variable regions but human heavy and light chain constant regions.
Is an important defense against intracellular pathogens
Type IV hypersensitivity
Can be induced by penicillin
All four types
Involves histamine as an important mediator
Type I and III hypersensitivity
Mice infected with Nippostrongulus brasiliensis exhibit decreased production of IgE
False: IgE is increased
IL-4 decreases IgE production by B cells
False: IL-4 increases IgE production
The initial step in the process of mast cell degranulation is cross linking of Fc receptors.
TRUE
Antihistamines are effective for the treatment of type III hypersensitivity
False: Antihistamines are helpful in the type I hypersensitivities, which involves release of histamines by mast cell degranulation. Because type III hypersensitivity involves immune complex deposition, antihistamines are ineffective.
Most pollen allergens contain a single allergenic component.
False: Most allergens contain multiple allergenic components.
Babies can acquire IgE-mediated allergies by passive transfer of maternal antibodies.
False: Unlike IgG, IgE cannot pass through the placenta
Transfusion reaction are a manifestation of type II hypersensitivity
TRUE
or with Fab fragments of such antibodies. Predict the response expected with each type of antibody."
"The complete antibodies would crosslink FcE RI molecules on the membrane of mast cells
induce vasodilation, smooth muscle contraction, and a local wheal and flare reaction. Because the fab fragment is monovalent, it cannot crosslink FcERI molecules and thus cannot induce degranulation. However this type of antireceptor antibody could bind to FcERI and might thereby block binding of IgE to the receptors."
or with Fab fragments of such antibodies. Would the response observed depend on whether the response observed depend on whether the mice were allergic?"
The response induced by complete anti-FceRI antibodies does not depend on allergen specific IgE and thus would be similar in allergic and nonallergic mice. Injection of Fab fragments of anti-FceRI might prevent allergic mice from reacting to an allergen if these fragments block binding of IgE to mast cells and basophiles.
advances to produce an antitoxin that would not produce serum sickness in patients who receive it?"
Engineer chimeric monoclonal antibodies to snake venom that contain mouse variable regions but human heavy and light chain constant regions.
within 1-2 min after being bitten, swelling and redness appear at the site and then disappear in 1 hour."
"Type I hypersensitivity: localized atopic reaction that results from allergen cross linkage
of fixed IgE on skin of mast cells, inducing degranulation and mediator release."
after an insect bite 6 to 8 hours later, swelling and redness again appear and persist for 24 hours."
"Type III hypersensitivity: immune complexes of antibody and insect antigens from a and
are deposited locally, causing an Arthus type reaction resulting from complement activation and complement split products."
after an insect bite 72 hours later, the tissue becomes inflamed, and tissue necrosis follows."
"Type IV hypersensitivity: sensitized Th cells release their mediators, inducing macrophage
accumulation and activation. Tissue damage results from lysosomal enzymes released by the macrophages."
Is an important defense against intracellular pathogens
Type IV hypersensitivity
Can be induced by penicillin
All four types
Involves histamine as an important mediator
Type I and III hypersensitivity
Can be induced by poison oak in sensitive individuals
Type IV hypersensitivity
Can lead to asthma
Type I hypersensitivity
Occurs as result of mismatched blood transfusions
Type II hypersensitivity
Systemic form of reaction is treated with epinephrine
Type I hypersensitivity
Can be induced by pollens and certain foods in sensitive individuals
Type I hypersensitivity
May involve cell destruction by antibody dependent cell mediated cytoxicity
Type II hypersensitivity
One form of clinical manifestation is prevented by Rhogam
Type II hypersensitivity
Localized form characterized by wheal and flare reactions
Type I hypersensitivity
IgE mediated degranulation of mast cells
Type I hypersensitivity
Lysis of antibody coated blood cells by complement
Type II hypersensitivity
Tissue destruction in response to poison oak
Type IV hypersensitivity
C3a and C5a mediated mast cell degranulation
Type III hypersensitivity and some type II
Chemotaxis of neutrophils
Type III hypersensitivity
Chemotaxis of eosinophils
Type I hypersensitivity
Activation of macrophages by IFN-gamma
Type IV hypersensitivity
Deposition of antigen-antibody complexes on basement membranes of capillaries
Type I hypersensitivity
advances to produce an antitoxin that would not produce serum sickness in patients who receive it?"
Engineer chimeric monoclonal antibodies to snake venom that contain mouse variable regions but human heavy and light chain constant regions.
within 1-2 min after being bitten, swelling and redness appear at the site and then disappear in 1 hour."
"Type I hypersensitivity: localized atopic reaction that results from allergen cross linkage
of fixed IgE on skin of mast cells, inducing degranulation and mediator release."
after an insect bite 6 to 8 hours later, swelling and redness again appear and persist for 24 hours."
"Type III hypersensitivity: immune complexes of antibody and insect antigens from a and
are deposited locally, causing an Arthus type reaction resulting from complement activation and complement split products."
after an insect bite 72 hours later, the tissue becomes inflamed, and tissue necrosis follows."
"Type IV hypersensitivity: sensitized Th cells release their mediators, inducing macrophage
accumulation and activation. Tissue damage results from lysosomal enzymes released by the macrophages."
Is an important defense against intracellular pathogens
Type IV hypersensitivity
Can be induced by penicillin
All four types
Involves histamine as an important mediator
Type I and III hypersensitivity
Can be induced by poison oak in sensitive individuals
Type IV hypersensitivity
Can lead to asthma
Type I hypersensitivity
Occurs as result of mismatched blood transfusions
Type II hypersensitivity
Systemic form of reaction is treated with epinephrine
Type I hypersensitivity
Can be induced by pollens and certain foods in sensitive individuals
Type I hypersensitivity
May involve cell destruction by antibody dependent cell mediated cytoxicity
Type II hypersensitivity
One form of clinical manifestation is prevented by Rhogam
Type II hypersensitivity
Localized form characterized by wheal and flare reactions
Type I hypersensitivity
IgE mediated degranulation of mast cells
Type I hypersensitivity
Lysis of antibody coated blood cells by complement
Type II hypersensitivity
Tissue destruction in response to poison oak
Type IV hypersensitivity
C3a and C5a mediated mast cell degranulation
Type III hypersensitivity and some type II
Chemotaxis of neutrophils
Type III hypersensitivity
Chemotaxis of eosinophils
Type I hypersensitivity
Activation of macrophages by IFN-gamma
Type IV hypersensitivity
Deposition of antigen-antibody complexes on basement membranes of capillaries
Type I hypersensitivity
Mice infected with Nippostrongulus brasiliensis exhibit decreased production of IgE
False: IgE is increased
IL-4 decreases IgE production by B cells
False: IL-4 increases IgE production
The initial step in the process of mast cell degranulation is cross linking of Fc receptors.
TRUE
Antihistamines are effective for the treatment of type III hypersensitivity
False: Antihistamines are helpful in the type I hypersensitivities, which involves release of histamines by mast cell degranulation. Because type III hypersensitivity involves immune complex deposition, antihistamines are ineffective.
Most pollen allergens contain a single allergenic component.
False: Most allergens contain multiple allergenic components.
Babies can acquire IgE-mediated allergies by passive transfer of maternal antibodies.
False: Unlike IgG, IgE cannot pass through the placenta
Transfusion reaction are a manifestation of type II hypersensitivity
TRUE
or with Fab fragments of such antibodies. Predict the response expected with each type of antibody."
"The complete antibodies would crosslink FcE RI molecules on the membrane of mast cells
induce vasodilation, smooth muscle contraction, and a local wheal and flare reaction. Because the fab fragment is monovalent, it cannot crosslink FcERI molecules and thus cannot induce degranulation. However this type of antireceptor antibody could bind to FcERI and might thereby block binding of IgE to the receptors."
or with Fab fragments of such antibodies. Would the response observed depend on whether the response observed depend on whether the mice were allergic?"
The response induced by complete anti-FceRI antibodies does not depend on allergen specific IgE and thus would be similar in allergic and nonallergic mice. Injection of Fab fragments of anti-FceRI might prevent allergic mice from reacting to an allergen if these fragments block binding of IgE to mast cells and basophiles.
advances to produce an antitoxin that would not produce serum sickness in patients who receive it?"
Engineer chimeric monoclonal antibodies to snake venom that contain mouse variable regions but human heavy and light chain constant regions.
within 1-2 min after being bitten, swelling and redness appear at the site and then disappear in 1 hour."
"Type I hypersensitivity: localized atopic reaction that results from allergen cross linkage
of fixed IgE on skin of mast cells, inducing degranulation and mediator release."
after an insect bite 6 to 8 hours later, swelling and redness again appear and persist for 24 hours."
"Type III hypersensitivity: immune complexes of antibody and insect antigens from a and
are deposited locally, causing an Arthus type reaction resulting from complement activation and complement split products."
after an insect bite 72 hours later, the tissue becomes inflamed, and tissue necrosis follows."
"Type IV hypersensitivity: sensitized Th cells release their mediators, inducing macrophage
accumulation and activation. Tissue damage results from lysosomal enzymes released by the macrophages."
Is an important defense against intracellular pathogens
Type IV hypersensitivity
Can be induced by penicillin
All four types
Mice infected with Nippostrongulus brasiliensis exhibit decreased production of IgE
False: IgE is increased
IL-4 decreases IgE production by B cells
False: IL-4 increases IgE production
The initial step in the process of mast cell degranulation is cross linking of Fc receptors.
TRUE
Antihistamines are effective for the treatment of type III hypersensitivity
False: Antihistamines are helpful in the type I hypersensitivities, which involves release of histamines by mast cell degranulation. Because type III hypersensitivity involves immune complex deposition, antihistamines are ineffective.
Most pollen allergens contain a single allergenic component.
False: Most allergens contain multiple allergenic components.
Babies can acquire IgE-mediated allergies by passive transfer of maternal antibodies.
False: Unlike IgG, IgE cannot pass through the placenta
Transfusion reaction are a manifestation of type II hypersensitivity
TRUE
or with Fab fragments of such antibodies. Predict the response expected with each type of antibody."
"The complete antibodies would crosslink FcE RI molecules on the membrane of mast cells
induce vasodilation, smooth muscle contraction, and a local wheal and flare reaction. Because the fab fragment is monovalent, it cannot crosslink FcERI molecules and thus cannot induce degranulation. However this type of antireceptor antibody could bind to FcERI and might thereby block binding of IgE to the receptors."
or with Fab fragments of such antibodies. Would the response observed depend on whether the response observed depend on whether the mice were allergic?"
The response induced by complete anti-FceRI antibodies does not depend on allergen specific IgE and thus would be similar in allergic and nonallergic mice. Injection of Fab fragments of anti-FceRI might prevent allergic mice from reacting to an allergen if these fragments block binding of IgE to mast cells and basophiles.
advances to produce an antitoxin that would not produce serum sickness in patients who receive it?"
Engineer chimeric monoclonal antibodies to snake venom that contain mouse variable regions but human heavy and light chain constant regions.
within 1-2 min after being bitten, swelling and redness appear at the site and then disappear in 1 hour."
"Type I hypersensitivity: localized atopic reaction that results from allergen cross linkage
of fixed IgE on skin of mast cells, inducing degranulation and mediator release."
after an insect bite 6 to 8 hours later, swelling and redness again appear and persist for 24 hours."
"Type III hypersensitivity: immune complexes of antibody and insect antigens from a and
are deposited locally, causing an Arthus type reaction resulting from complement activation and complement split products."
What immunological mechanisms most like account for a person's developing each of the following reactions after an insect bite 72 hours later, the tissue becomes inflamed, and tissue necrosis follows.
Type IV hypersensitivity: sensitized Th cells release their mediators, inducing macrophage cumulation and activation. Tissue damage results from lysosomal enzymes released by the macrophages.
Is an important defense against intracellular pathogens
Type IV hypersensitivity
Can be induced by penicillin
All four types
Involves histamine as an important mediator
Type I and III hypersensitivity
Can be induced by poison oak in sensitive individuals
Type IV hypersensitivity
Can lead to asthma
Type I hypersensitivity
Occurs as result of mismatched blood transfusions
Type II hypersensitivity
Systemic form of reaction is treated with epinephrine
Type I hypersensitivity
Can be induced by pollens and certain foods in sensitive individuals
Type I hypersensitivity
May involve cell destruction by antibody dependent cell mediated cytoxicity
Type II hypersensitivity
One form of clinical manifestation is prevented by Rhogam
Type II hypersensitivity
Localized form characterized by wheal and flare reactions
Type I hypersensitivity
IgE mediated degranulation of mast cells
Type I hypersensitivity
Lysis of antibody coated blood cells by complement
Type II hypersensitivity
Tissue destruction in response to poison oak
Type IV hypersensitivity
C3a and C5a mediated mast cell degranulation
Type III hypersensitivity and some type II
Chemotaxis of neutrophils
Type III hypersensitivity
Chemotaxis of eosinophils
Type I hypersensitivity
Activation of macrophages by IFN-gamma
Type IV hypersensitivity
Deposition of antigen-antibody complexes on basement membranes of capillaries
Type I hypersensitivity
Mice infected with Nippostrongulus brasiliensis exhibit decreased production of IgE
False: IgE is increased
IL-4 decreases IgE production by B cells
False: IL-4 increases IgE production
The initial step in the process of mast cell degranulation is cross linking of Fc receptors.
TRUE
Antihistamines are effective for the treatment of type III hypersensitivity
False: Antihistamines are helpful in the type I hypersensitivities, which involves release of histamines by mast cell degranulation. Because type III hypersensitivity involves immune complex deposition, antihistamines are ineffective.
Most pollen allergens contain a single allergenic component.
False: Most allergens contain multiple allergenic components.
Babies can acquire IgE-mediated allergies by passive transfer of maternal antibodies.
False: Unlike IgG, IgE cannot pass through the placenta
Transfusion reaction are a manifestation of type II hypersensitivity
TRUE
or with Fab fragments of such antibodies. Predict the response expected with each type of antibody."
"The complete antibodies would crosslink FcE RI molecules on the membrane of mast cells
induce vasodilation, smooth muscle contraction, and a local wheal and flare reaction. Because the fab fragment is monovalent, it cannot crosslink FcERI molecules and thus cannot induce degranulation. However this type of antireceptor antibody could bind to FcERI and might thereby block binding of IgE to the receptors."
or with Fab fragments of such antibodies. Would the response observed depend on whether the response observed depend on whether the mice were allergic?"
The response induced by complete anti-FceRI antibodies does not depend on allergen specific IgE and thus would be similar in allergic and nonallergic mice. Injection of Fab fragments of anti-FceRI might prevent allergic mice from reacting to an allergen if these fragments block binding of IgE to mast cells and basophiles.
advances to produce an antitoxin that would not produce serum sickness in patients who receive it?"
Engineer chimeric monoclonal antibodies to snake venom that contain mouse variable regions but human heavy and light chain constant regions.
within 1-2 min after being bitten, swelling and redness appear at the site and then disappear in 1 hour."
"Type I hypersensitivity: localized atopic reaction that results from allergen cross linkage
of fixed IgE on skin of mast cells, inducing degranulation and mediator release."
after an insect bite 6 to 8 hours later, swelling and redness again appear and persist for 24 hours."
"Type III hypersensitivity: immune complexes of antibody and insect antigens from a and
are deposited locally, causing an Arthus type reaction resulting from complement activation and complement split products."
What immunological mechanisms most like account for a person's developing each of the following reactions after an insect bite 72 hours later, the tissue becomes inflamed, and tissue necrosis follows.
Type IV hypersensitivity: sensitized Th cells release their mediators, inducing macrophage cumulation and activation. Tissue damage results from lysosomal enzymes released by the macrophages.
Is an important defense against intracellular pathogens
Type IV hypersensitivity
Can be induced by penicillin
All four types
Involves histamine as an important mediator
Type I and III hypersensitivity
Can be induced by poison oak in sensitive individuals
Type IV hypersensitivity
Can lead to asthma
Type I hypersensitivity
Occurs as result of mismatched blood transfusions
Type II hypersensitivity
Systemic form of reaction is treated with epinephrine
Type I hypersensitivity
Can be induced by pollens and certain foods in sensitive individuals
Type I hypersensitivity
May involve cell destruction by antibody dependent cell mediated cytoxicity
Type II hypersensitivity
One form of clinical manifestation is prevented by Rhogam
Type II hypersensitivity
Localized form characterized by wheal and flare reactions
Type I hypersensitivity
IgE mediated degranulation of mast cells
Type I hypersensitivity
Lysis of antibody coated blood cells by complement
Type II hypersensitivity
Tissue destruction in response to poison oak
Type IV hypersensitivity
C3a and C5a mediated mast cell degranulation
Type III hypersensitivity and some type II
Chemotaxis of neutrophils
Type III hypersensitivity
Chemotaxis of eosinophils
Type I hypersensitivity
Activation of macrophages by IFN-gamma
Type IV hypersensitivity
Deposition of antigen-antibody complexes on basement membranes of capillaries
Type I hypersensitivity
False: IgE is increased
False: IL-4 increases IgE production
TRUE
False: Antihistamines are helpful in the type I hypersensitivities, which involves release of histamines by mast cell degranulation. Because type III hypersensitivity involves immune complex deposition, antihistamines are ineffective.
False: Most allergens contain multiple allergenic components.
False: Unlike IgG, IgE cannot pass through the placenta
TRUE
induce vasodilation, smooth muscle contraction, and a local wheal and flare reaction. Because the fab fragment is monovalent, it cannot crosslink FcERI molecules and thus cannot induce degranulation. However this type of antireceptor antibody could bind to FcERI and might thereby block binding of IgE to the receptors."
The response induced by complete anti-FceRI antibodies does not depend on allergen specific IgE and thus would be similar in allergic and nonallergic mice. Injection of Fab fragments of anti-FceRI might prevent allergic mice from reacting to an allergen if these fragments block binding of IgE to mast cells and basophiles.
Engineer chimeric monoclonal antibodies to snake venom that contain mouse variable regions but human heavy and light chain constant regions.
of fixed IgE on skin of mast cells, inducing degranulation and mediator release."
are deposited locally, causing an Arthus type reaction resulting from complement activation and complement split products."
Type IV hypersensitivity: sensitized Th cells release their mediators, inducing macrophage cumulation and activation. Tissue damage results from lysosomal enzymes released by the macrophages.
Type IV hypersensitivity
All four types
Type I and III hypersensitivity
Type IV hypersensitivity
Type I hypersensitivity
Type II hypersensitivity
Type I hypersensitivity
Type I hypersensitivity
Type II hypersensitivity
Type II hypersensitivity
Type I hypersensitivity
Type I hypersensitivity
Type II hypersensitivity
Type IV hypersensitivity
Type III hypersensitivity and some type II
Type III hypersensitivity
Type I hypersensitivity
Type IV hypersensitivity
Type I hypersensitivity
Mice infected with Nippostrongulus brasiliensis exhibit decreased production of IgE
False: IgE is increased
IL-4 decreases IgE production by B cells
False: IL-4 increases IgE production
The initial step in the process of mast cell degranulation is cross linking of Fc receptors.
TRUE
Antihistamines are effective for the treatment of type III hypersensitivity
False: Antihistamines are helpful in the type I hypersensitivities, which involves release of histamines by mast cell degranulation. Because type III hypersensitivity involves immune complex deposition, antihistamines are ineffective.
Most pollen allergens contain a single allergenic component.
False: Most allergens contain multiple allergenic components.
Babies can acquire IgE-mediated allergies by passive transfer of maternal antibodies.
False: Unlike IgG, IgE cannot pass through the placenta
Transfusion reaction are a manifestation of type II hypersensitivity
TRUE
or with Fab fragments of such antibodies. Would the response observed depend on whether the response observed depend on whether the mice were allergic?"
The response induced by complete anti-FceRI antibodies does not depend on allergen specific IgE and thus would be similar in allergic and nonallergic mice. Injection of Fab fragments of anti-FceRI might prevent allergic mice from reacting to an allergen if these fragments block binding of IgE to mast cells and basophiles.
advances to produce an antitoxin that would not produce serum sickness in patients who receive it?"
Engineer chimeric monoclonal antibodies to snake venom that contain mouse variable regions but human heavy and light chain constant regions.
What immunological mechanisms most like account for a person's developing each of the following reactions after an insect bite 72 hours later, the tissue becomes inflamed, and tissue necrosis follows.
Type IV hypersensitivity: sensitized Th cells release their mediators, inducing macrophage cumulation and activation. Tissue damage results from lysosomal enzymes released by the macrophages.
Is an important defense against intracellular pathogens
Type IV hypersensitivity
Can be induced by penicillin
All four types
Involves histamine as an important mediator
Type I and III hypersensitivity
Mice infected with Nippostrongulus brasiliensis exhibit decreased production of IgE
False: IgE is increased
IL-4 decreases IgE production by B cells
False: IL-4 increases IgE production
The initial step in the process of mast cell degranulation is cross linking of Fc receptors.
TRUE
Antihistamines are effective for the treatment of type III hypersensitivity
False: Antihistamines are helpful in the type I hypersensitivities, which involves release of histamines by mast cell degranulation. Because type III hypersensitivity involves immune complex deposition, antihistamines are ineffective.
Most pollen allergens contain a single allergenic component.
False: Most allergens contain multiple allergenic components.
Babies can acquire IgE-mediated allergies by passive transfer of maternal antibodies.
False: Unlike IgG, IgE cannot pass through the placenta
Transfusion reaction are a manifestation of type II hypersensitivity
TRUE
or with Fab fragments of such antibodies. Would the response observed depend on whether the response observed depend on whether the mice were allergic?"
The response induced by complete anti-FceRI antibodies does not depend on allergen specific IgE and thus would be similar in allergic and nonallergic mice. Injection of Fab fragments of anti-FceRI might prevent allergic mice from reacting to an allergen if these fragments block binding of IgE to mast cells and basophiles.
advances to produce an antitoxin that would not produce serum sickness in patients who receive it?"
Engineer chimeric monoclonal antibodies to snake venom that contain mouse variable regions but human heavy and light chain constant regions.
What immunological mechanisms most like account for a person's developing each of the following reactions after an insect bite 72 hours later, the tissue becomes inflamed, and tissue necrosis follows.
Type IV hypersensitivity: sensitized Th cells release their mediators, inducing macrophage cumulation and activation. Tissue damage results from lysosomal enzymes released by the macrophages.
Mice infected with Nippostrongulus brasiliensis exhibit decreased production of IgE
False: IgE is increased
IL-4 decreases IgE production by B cells
False: IL-4 increases IgE production
The initial step in the process of mast cell degranulation is cross linking of Fc receptors.
TRUE
Antihistamines are effective for the treatment of type III hypersensitivity
False: Antihistamines are helpful in the type I hypersensitivities, which involves release of histamines by mast cell degranulation. Because type III hypersensitivity involves immune complex deposition, antihistamines are ineffective.
Most pollen allergens contain a single allergenic component.
False: Most allergens contain multiple allergenic components.
Babies can acquire IgE-mediated allergies by passive transfer of maternal antibodies.
False: Unlike IgG, IgE cannot pass through the placenta
Transfusion reaction are a manifestation of type II hypersensitivity
TRUE
"Mice injected intradermally with complete antibodies to the IgE Fc receptor (FcERI)
or with Fab fragments of such antibodies. Predict the response expected with each type of antibody."
"The complete antibodies would crosslink FcE RI molecules on the membrane of mast cells
and basophiles, resulting in their activation and degranulation. The released mediators would
induce vasodilation, smooth muscle contraction, and a local wheal and flare reaction. Because the fab fragment is monovalent, it cannot crosslink FcERI molecules and thus cannot induce degranulation. However this type of antireceptor antibody could bind to FcERI and might thereby block binding of IgE to the receptors."
"Mice injected intradermally with complete antibodies to the IgE Fc receptor (FcERI)
or with Fab fragments of such antibodies. Would the response observed depend on whether the response observed depend on whether the mice were allergic?"
The response induced by complete anti-FceRI antibodies does not depend on allergen specific IgE and thus would be similar in allergic and nonallergic mice. Injection of Fab fragments of anti-FceRI might prevent allergic mice from reacting to an allergen if these fragments block binding of IgE to mast cells and basophiles.
"Serum sickness can result when an individual is given a large dose of antiserum such as a mouse antitoxin to snake venom. How could you take advantage of recent technological
advances to produce an antitoxin that would not produce serum sickness in patients who receive it?"
Engineer chimeric monoclonal antibodies to snake venom that contain mouse variable regions but human heavy and light chain constant regions.
"What immunological mechanisms most like account for a person's developing each of the following reactions after an insect bite
within 1-2 min after being bitten, swelling and redness appear at the site and then disappear in 1 hour."
"Type I hypersensitivity: localized atopic reaction that results from allergen cross linkage
of fixed IgE on skin of mast cells, inducing degranulation and mediator release."
"What immunological mechanisms most like account for a person's developing each of the following reactions
after an insect bite 6 to 8 hours later, swelling and redness again appear and persist for 24 hours."
"Type III hypersensitivity: immune complexes of antibody and insect antigens from a and
are deposited locally, causing an Arthus type reaction resulting from complement activation and complement split products."
What immunological mechanisms most like account for a person's developing each of the following reactions after an insect bite 72 hours later, the tissue becomes inflamed, and tissue necrosis follows.
Type IV hypersensitivity: sensitized Th cells release their mediators, inducing macrophage cumulation and activation. Tissue damage results from lysosomal enzymes released by the macrophages.
Is an important defense against intracellular pathogens
Type IV hypersensitivity
Can be induced by penicillin
All four types