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15 Cards in this Set
- Front
- Back
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problem:
total calcium 8.2 albumin 2.6 corrected Ca |
corrected calcium=total calcium(measured) + ([normal albumin-patients albumin] x 0.8)
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two dyes use to measure calcium
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orthocresolphthalein complexone
arsenazo |
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why does hemolysis give falsely elevated phosphorus levels?
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organic esters are hydrolyzed during storage to inorganic phosphate as red cells hemolyze, a hemolyzed sample will accomplish the same thing
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Reagent most commonly used to measure total magnesium
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Photometric methods using metallochromic dyes which bind magnesium.....calmagite method
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Two cations that simulate the parathyroid to release PTH
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Ca and Mg
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Analytic technique is used to measure PTH intraoperatively
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Immunochemiluminometric assay is used intraoperatively. It is less sensitive but more than adequate to measure the large drops in PTH seen during surgery
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PTHrP
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PTHrP shares the same receptor as PTH, so end organ effect is similar
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Hypercalcemia in sarcoidosis
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Granulomatous tissue produces1,25(OH)2D3, just as the kidney does. The increase in active vitamin D increases calcium absorption from the intestines to raise blood calcium
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90% of hypercalcemia cases caused by?...
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Primary hperparathyroidism and malignancy
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Most severe bone manifestation of hyperparathyroidism
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Osteitis fibrosa cystica
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Differentiate between the pathophysiology of type I and type II vitamin D rickets
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I; decreased activity of renal enzyme 1-alpha hydroxylase, if given calcitriol they respond to generate normal levels of active vit D
II;mutations of the receptor 1,25(OH)2D, active vitamin D can not enter the cells |
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Most common cause of hypophosphatemia?
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Renal failure
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Hypomagnesemia caused by...
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Alcohol, loop diuretics, diabetes, diarrhea
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Collagen breakdown product specific for bone and correlates with bone turnover?
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Pyridinium crosslink called deoxypyridinoline (Dpyr) is a good marker
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Pathophysiology and key cell lines in osteoporosis in a 53yo v 83yo?
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Post menopausal : excessive osteoclastic activity
In the senile form: cortical bone loss |
