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13 Cards in this Set
- Front
- Back
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What is pathogenic latency? Give an example.
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The pathogen ceases to replicate until immunity wanes. An example is the herpes virus - fever blisters emerge when stressed/tired.
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How does TSST-1 Ag (a super Ag) work?
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It suppresses the immune system by binding the TCR and causing the T Cell to produce immunosuppressive cytokines.
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Which gender is more susceptible to inherited immune deficiencies, male or female? Why?
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Males are more susceptible b/c most genetic immunodeficiencies are on the X chromosome.
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What is Chediak-Higashi syndrome?
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A phagoctyic disease where lysosomal fusion with phagosomes is impaired.
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What is chronic granulomatous disease?
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In Chronic granulomatous disease, phagocytes cannot produce the superoxide radical, there their bacterialcidal activity is reduced.
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What is Bruton’s X-linked agammaglobulinemia (XLA)?
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A deficiency in BTK (protein kinase) that results in B Cell maturation halting at the pre-b cell stage. Ergo, no B cells or Igs!
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What is X linked hyper-IgM syndrome?
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CD40L on activated T cells cannot engage CD40 on B cells (which are normal). No isotype switching occurs and only IgM is produced.
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What is Severe combined immune deficiency (SCID)?
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A lymphocyte deficiency that results from T cell mutations that, in turn, compromise B cells.
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Deficiencies in RAG-1 and RAG-2 cause what?
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Failed T and B cell responses due to a lack of TCR or BCR development.
T cells can fail to develop due to mutations in cytokine receptors that drive development. |
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What is Bare lymphocyte syndrome? What does this cause?
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A lack of MHC II products on cells. This inhibits positive selection of CD4 T cells. However, patients still have proper CD8 T cells function
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What is Di George syndrome?
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Thymic epithelium develops abnormally and T cells fail to develop properly. No CD4 or CD8 Tcells, impaired B cell activation
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If a patient has a deficiency in complement, what problems are they likely to have?
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They will have problems clearing immune complexes, that can't rid of Neisseria species, and they are more susceptible to extracellular pathogens.
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What receptor does HIV associate with and what cell is a marker of HIV disease progression?
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CD4. CD4 cell levels indicate disease progression.
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