Chapt. 43 Drugs Acting On Raas

Front 1

This syst. plays an important role in reg. BP, blood vol. & fluid electrolyte balance. Exerts it effects through angiotensin II & aldosterone. Raises BP by vasoconstriction & renal retention of water & Na+.

Back 1

RAAS

Front 2

A small polypeptide that's the precursor of Angiotensin II & has very high biological activity.

Back 2

Angiotensin I

Front 3

Participates in all processes reg. by RAAS. Most prominent actions are vaso-CONSTICTION & stim. of aldosterone release. Can act on heart & vessles to cause patho change.

Back 3

Angiotensin II

Front 4

A small polypepetide that is formed by the degradation of angiotensin II & has moderate bio activity.

Back 4

Angiotensin III

Front 5

Angiotensin II most powerful action is this. Compound acts directly on vascular smooth muscle causing contraction. Acts indirectly on sympathetic neurons to promote norepi relase & adrenal medulla to promote epi release & CNS to increase sympathetic outflow of blood vessles.

Back 5

Vasoconstriction

Front 6

Angiotensin II acts on adrenal cortext to promote synthesis & secretion of this, which can stim. it's release. Secretion is enhanced when Na+ is lvls are low & K+ levels are high.

Back 6

Aldosterone

Front 7

Following the release of this from the adrenal cortext, this acts on the kidney to cause retention of Na+ & excretion of K+ & H-. Retension of Na+ increases blood vol. which increases BP. (Repeat Question)


(Repeat Question)

Back 7

Aldosterone

Front 8

This is produced by the juxtaglomular cells of the kidney, where it converts angiotensin into angiotensin I. Release increases in response to declines in BP blood vol. plasma, Na+ & renal perfusion pressure.

Back 8

Renin

Front 9

This catalyzes the conversion of angiotensin I to angiotensin II. It's loc. on the luminal surface of all blood vessels, vasculature of the lungs being especially rich with this enzyme.

Back 9

ACE

Front 10

Important drugs in treating HT, heart failure, diabetic neuropathy & MI. Produce beneficial effects by reducing lvls of angiotensin I & increasing bradykinin.

Back 10

ACE Inhibitors

Front 11

This syst. plays an important role in reg. BP, blood vol. & fluid electrolyte balance. Exerts it effects through angiotensin II & aldosterone

Back 11

RAAS

Front 12

A small polypeptide that's the precursor of Angiotensin II & has very high biological activity.

Back 12

Angiotensin I

Front 13

Participates in all processes reg. by RAAS. Most prominent actions are vaso-CONSTICTION & stim. of aldosterone release. Can act on heart & vessles to cause patho change.

Back 13

Angiotensin II

Front 14

A small polypepetide that is formed by the degradation of angiotensin II & has moderate bio activity.

Back 14

Angiotensin III

Front 15

Angiotensin II most powerful action is this. Compound acts directly on vascular smooth muscle causing contraction. Acts indirectly on sympathetic neurons to promote norepi relase & adrenal medulla to promote epi release & CNS to increase sympathetic outflow of blood vessles.

Back 15

Vasoconstriction

Front 16

This is produced by the juxtaglomerular cells of the kidney. It's release increases in response to a decline in BP & blood volume, Na+ content or renal pefusion pressure.

Back 16

Renin

Front 17

Enzyme that catalyzes the conversion of angiotensin I to II, loc. on the luminal surface of all blood vessels & vasculature of the lungs.

Back 17

ACE

Front 18

Important drugs for treating HT, HF, diabetic nephrpathy & MI. Adverse effects are cough, angioedema, first-dose-hypotension, & hypekalemia. Benefits result largely from suppressing angiotensin II

Back 18

ACE Inhibitors

Front 19

The action of this ACE inhibitor acts by blocking conversion of Angiotensin I to II while inactivating bradykinin. Also increases renin lvls & reduces aldosterone lvls. Indication are for HT, HF, LVD after

Back 19

Captopril

Front 20

Pharmokinetics of this drug has a half life of <2hrs. & at least 75% absorbed following oral administration.

Back 20

Captopril

Front 21

Hypersensitivity, Cross sensitivity among ACE Inhibitors may occur, Preganancy & Angioedema are all factors for what with Captopril.

Back 21

Precautions/Contraindications

Front 22

Excessive hypo-tension may occurr when Captopril is used in conjunction w/diuretics or antihypertensives. This is an example of what?

Back 22

Interactions

Front 23

Cough & Hypotension are what kind of effects with Captopril?

Back 23

Adverse Effects

Front 24

These drugs decrease the influence of angiotensin II by blocking the "actions" of angiotensin II without causing cough or hyperkalemia. All are taken orally.

Back 24

ARB's

Front 25

Action of this drug blocks vasoconstriction & aldosterone producing effects of angiotensin II at VSM & adrenal glands.

Back 25

Losartan

Front 26

NSAID may lower antihypetensive effects. Other antihypersensitive drugs may increase effects along with diuretics. Risk of hypotension. These are all indications for which drug.

Back 26

Losartan

Front 27

Hypersensitivity, pregnancy or laction are what considerations for Losartan.

Back 27

Precautions/Contraindications

Front 28

Hypotension & hyperkalemia are what kind of effect for Losartan.

Back 28

Adverse Effects

Front 29

Asses BP & signs of angioedema should occur at what stage of admission?

Back 29

Pre-administration assessment