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28 Cards in this Set
- Front
- Back
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the definition of autoimmunity is?
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decreased tolerance to "self" immunity
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Lupus is organ specific or non-specific
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non-specific
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antibodies demonstrated in pernicious anemia
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anti-intrinsic factor and antiparietal
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the basic immunologic mechanism responsible for autoimmune disorders is related to?
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deposition of circulating immune complexes
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anticardiolipin antibody is associated with
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systemic lupus erythematosus
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anti- DNA antibody is associated with
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systemic lupus erythematosus
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antimyelin antibody antibody is associated with
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multiple sclerosis
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an early marker of beta pancreatic cell destruction is __________ antibody.
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anti-islet cell
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the immunologic manifestations of MS does not include?
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myelin antibodies are detectable in the CSF of MS patients
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Pernicious aemia is characterized by
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defiency of vitamin B12
presence of antiparietal antibodies presence of IF-blocking antibodies |
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the most common form of lupus is
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systemic
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SLE is more common in
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women
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the overall incidence of SLE has increased frequency among
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people of color
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the most frequent cause of mortality in hospitalized SLE patients with progressive renal involvement or CNS disease is
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infection
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patients with SLE characteristically manifest
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photosensitivity facial rash
polyartritis dermatitis |
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laboratory features of SLE include
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the presence of ANA's
circulating anticoagulants and immune complexes decreased level of components |
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autoimmune disorder indicating an increased titer of anti-SM (anti-smith) antibody
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SLE
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many of the manifestations of SLE are a consequence of
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tissue damage mediated by immune complexes
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a diffused or homogeneous pattern in anti-nuclear antibody testing (ANA) characterizes
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nDNA, ds-DNA, histones, ssDNA, DNP, or histones
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A specled pattern in ANA testing characterizes
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anti-RNP and anti-SM
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Rheumatoid arthritis is characterized by
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joint pain and tenderness, the presence of rheumatoid factor in the blood, and associated with HLA-DR genes
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the immunoglobulin classes most often associated with rheumatoid factors are
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IgG and IgA
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immunoglobulins or molecular components used in rheumatoid factor rapid slide assays are
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Fc portion of IgG
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what are the antibody specifities and related disorders to a homogeneous ANA staining pattern
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nDNA and dsDNA - SLE
ssDNA - rheumatoid arthritis DNP - sjogrens syndrom histones - mixxed connective tissue disease |
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what are the antibody specifities and related disorders to a periferal or rim ANA stain pattern
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nDNA - active SLE
dsDNA or DNP- sjogrens syndrom |
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what are the antibody specifities and related disorders to a speckeled ANA stain pattern
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smith and RNP --- SLE, RA, sjogrens syndrome, PSS, MCTD
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what are the antibody specifities and related disorders to a nucleolar ANA stain pattern
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4-6s RNP --- scleroderma, sjogrens syndrome, or undiagnosed illnesses manifesting raynauds phenomenon
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what are the antibody specifities and related disorders to a discrete speckeled ANA stain pattern
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centromere, DNA, RNA, ENA --- CREST varient of PSS
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