• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/13

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

13 Cards in this Set

  • Front
  • Back

Megakaryocytes

-Largest cells in the body


-polyploid


-multilobulated, abundant granular

Platelets

-Trigger primary hemostasis on exposure to injury


-granular bht barely visible

Range of plt

150-400 x^9/L

Plt MPV

8-10fL

Endomitosis

Lacks telophase and anaphase

Megakaryocyte- erythrocyte progenitor

Differentiates into megakaryocyte lineage under the influence of hormine TPO and series of cytokines

3 megakaryocyte lineage committed progenitors

BFU-Meg


CFU-Meg


LD-CFU- Meg

Diploid


Normal mitosis


Maintaining pool of megakaryocyte progenitor

BFU-Meg


CFU-Meg

LD-CFU-Meg

Has little proliferative capacity, produces few cells, begins process through endomitosis

MK-1 stage/ Megakaryoblast

Least differentiated


Plasma membrane blebs

Mk-1 stage

Blunt projections from margin

Mk 1 cytoplasmic ultrastructure


Mk 1 cytoplasmic ultrastructure


Mk 1 cytoplasmic ultrastructure

Procoagulant-laden-a-granulesDelta granulesDemarcation system

Nuclear lobularity


Full ploidy by end of stage

MK 2 stage/ Promegakaryocyte