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13 Cards in this Set
- Front
- Back
Megakaryocytes |
-Largest cells in the body -polyploid -multilobulated, abundant granular |
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Platelets |
-Trigger primary hemostasis on exposure to injury -granular bht barely visible |
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Range of plt |
150-400 x^9/L |
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Plt MPV |
8-10fL |
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Endomitosis |
Lacks telophase and anaphase |
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Megakaryocyte- erythrocyte progenitor |
Differentiates into megakaryocyte lineage under the influence of hormine TPO and series of cytokines |
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3 megakaryocyte lineage committed progenitors |
BFU-Meg CFU-Meg LD-CFU- Meg |
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Diploid Normal mitosis Maintaining pool of megakaryocyte progenitor |
BFU-Meg CFU-Meg |
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LD-CFU-Meg |
Has little proliferative capacity, produces few cells, begins process through endomitosis |
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MK-1 stage/ Megakaryoblast |
Least differentiated Plasma membrane blebs |
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Mk-1 stage |
Blunt projections from margin |
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Mk 1 cytoplasmic ultrastructure Mk 1 cytoplasmic ultrastructure Mk 1 cytoplasmic ultrastructure |
Procoagulant-laden-a-granulesDelta granulesDemarcation system |
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Nuclear lobularity Full ploidy by end of stage |
MK 2 stage/ Promegakaryocyte |