Chap 12

Front 1

What is the primary goal or principle ofantimicrobial therapy?

Back 1

To Administer a drug to an infected person thatdestroys the infective agent without harming the host cells.

Front 2

The use of drugs to prevent potential for infection of a person at risk

Back 2

Prophylaxis

Front 3

What are antibiotics?

Back 3

common metabolic products of aerobic bacteria and fungi

Front 4

What two genera of bacteria and two genera ofmolds produce most antibiotics?

Back 4

Bacteria in genera: Streptomyces and BacillusMolds in genera: Penicillium and cephalosporium

Front 5

Why would bacteria produce antibiotics in the first place?

Back 5

antibiotic producer have less competition for nutrients andspace

Front 6

What is selective toxicity?

Back 6

Drugs should kill or inhibit microbial cells without simultaneouslydamaging host tissues

Front 7

Why is selective toxicity important?

Back 7

More side effects are seen without it

Front 8

Broad spectrum

Back 8

Greatest range of activity. Target cell components common tomost pathogens

Front 9

Narrow spectrum

Back 9

Effective on a small range of microbes. Target a specificcell component that is found only in certain microbes

Front 10

How does penicillin attack the cell wall?

Back 10

Blocks synthesis of peptydoclycan causes the cell wall to lyse

Front 11

What are the mechanisms that antiviral drugs use to prevent growth ofviruses?

Back 11

*Block penetration into host cell
*Block replication,transcription or translation of
*viral genetic material,
Prevent maturation ofviral particle

Front 12

What are interferons?

Back 12

Human-based glycoprotein produced primarily by fibroblastsand leukocytes

Front 13

What are the therapeutic benefits ofinterferons?

Back 13

Reduces healing time and come complications of infections,prevents or reduces symptoms of cold and papillomavirus, slows the progress ofcertain cancers, leukemia’s, and lymphomas, treatment of hepatitis C, Genitalwarts, Kaposi’s sarcoma.