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19 Cards in this Set
- Front
- Back
What does CCr correlate with?
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Correlates with GFR
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What factor normally causes a decrease in CCr?
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AGE
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What is the annual decrease in CCr?
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1ml/min beyond age 50
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Elderly patients normally have a decrease in CCr. Why is this so important?
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B/c you have to calculate the dose and dose interval for drugs that are nephrotoxic in order to avoid acute renal failure to nephrotoxic acute tubular necrosis.
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Name a class of drugs that can cause nephrotoxicity and can cause acute renal failure
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Amnoglycosides
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What is the CCr useful in detecting?
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REnal Dysfunction
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What is the formula for CCr?
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CCr= UCr (mg/dL) X V (mL/min) ÷PCr (mg/dL)
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How do you measure the volume for the Creatinine Clearance Calculation?
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1) Volume is a 24 hour collection in mL/min and UCr and PCr the creatinine concentration of urine and plasma
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What are the CCr results dependent on?
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A correct 24 hour urine collection
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What is the normal adult CCr?
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Is 97 to 137 mL/min
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In general, a CCr range below _______ is abnormal.
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below 100 mg/mL
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When does renal failure occur?
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Anything below 10mL/min
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What are the causes of increased CCr?
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1.Normal Pregnancy
2. Early Diabetic Glomerulopathy |
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What are the causes of decreased CCr?
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1. Elderly People
2. Acute and Chronic Renal Disease |
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Explain how normal pregnancy causes an increase in CCr.
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Normal increase in PV causes an increase in the GFR leading to an increase in CCr.
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When is CCr highest in pregnancy?
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The third trimester
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How does early diabetic glomerulopathy increase CCr?
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Efferent arteriole becomes constricted due to hyaline arteriosclerosis causing an increase in GFR and CCr.
Increase in GFR damages the glomerulus |
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Explain why you see a decrease in CCr in the elderly.
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GFR decreases with age thus causing a decrease in the CCr
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Explain how acute/chronic renal disease causes a decrease in CCr.
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ARF due to acute tubular necrosis
CRF due to diabetic neuropathy |