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19 Cards in this Set

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  • Back
What does CCr correlate with?
Correlates with GFR
What factor normally causes a decrease in CCr?
AGE
What is the annual decrease in CCr?
1ml/min beyond age 50
Elderly patients normally have a decrease in CCr. Why is this so important?
B/c you have to calculate the dose and dose interval for drugs that are nephrotoxic in order to avoid acute renal failure to nephrotoxic acute tubular necrosis.
Name a class of drugs that can cause nephrotoxicity and can cause acute renal failure
Amnoglycosides
What is the CCr useful in detecting?
REnal Dysfunction
What is the formula for CCr?
CCr= UCr (mg/dL) X V (mL/min) ÷PCr (mg/dL)
How do you measure the volume for the Creatinine Clearance Calculation?
1) Volume is a 24 hour collection in mL/min and UCr and PCr the creatinine concentration of urine and plasma
What are the CCr results dependent on?
A correct 24 hour urine collection
What is the normal adult CCr?
Is 97 to 137 mL/min
In general, a CCr range below _______ is abnormal.
below 100 mg/mL
When does renal failure occur?
Anything below 10mL/min
What are the causes of increased CCr?
1.Normal Pregnancy
2. Early Diabetic Glomerulopathy
What are the causes of decreased CCr?
1. Elderly People
2. Acute and Chronic Renal Disease
Explain how normal pregnancy causes an increase in CCr.
Normal increase in PV causes an increase in the GFR leading to an increase in CCr.
When is CCr highest in pregnancy?
The third trimester
How does early diabetic glomerulopathy increase CCr?
Efferent arteriole becomes constricted due to hyaline arteriosclerosis causing an increase in GFR and CCr.
Increase in GFR damages the glomerulus
Explain why you see a decrease in CCr in the elderly.
GFR decreases with age thus causing a decrease in the CCr
Explain how acute/chronic renal disease causes a decrease in CCr.
ARF due to acute tubular necrosis
CRF due to diabetic neuropathy