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5 Cards in this Set

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What is the cause or associated agent for Adult T-cell leukemia?
Malignant leukemia = HTLV-1
How does the T-cell Leukemia occur?
What genes are changed?
Activation of Tax gene, inhibits p53
leads to monoclonal proliferation of neoplastic CD4 T cells
What are the clinical findings for Adult-T- cell leukemia?
1.Hepatosplenomegaly and generalized lymphadenopathy
2. Skin infiltration
3. Lytic Bone Lesions
What causes the lytic bone lesions seen in T-cell leukemia?
1.Lymphoblast release osteoclast activating factor,
2. Associated with hypercalcemia
What are the Lab findings for T-cell Leukemia?
WBC
Anemia
Bone Marrow
WBC 10,000-50,000/uL
--20% lymphoblast
--Positive CD4 marker
--Negative TdT
2. Normocytic Anemia
3. Bone marrow Replaced by CD4 Lymphoblast