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5 Cards in this Set
- Front
- Back
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What is the cause or associated agent for Adult T-cell leukemia?
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Malignant leukemia = HTLV-1
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How does the T-cell Leukemia occur?
What genes are changed? |
Activation of Tax gene, inhibits p53
leads to monoclonal proliferation of neoplastic CD4 T cells |
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What are the clinical findings for Adult-T- cell leukemia?
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1.Hepatosplenomegaly and generalized lymphadenopathy
2. Skin infiltration 3. Lytic Bone Lesions |
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What causes the lytic bone lesions seen in T-cell leukemia?
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1.Lymphoblast release osteoclast activating factor,
2. Associated with hypercalcemia |
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What are the Lab findings for T-cell Leukemia?
WBC Anemia Bone Marrow |
WBC 10,000-50,000/uL
--20% lymphoblast --Positive CD4 marker --Negative TdT 2. Normocytic Anemia 3. Bone marrow Replaced by CD4 Lymphoblast |
