Ch. 7 - Cognitive Decline During Migraine And Cluster Headaches Are Caused By Cerebral 5Ht Neurotransmitter Dysfunction

Front 1

Cause of Migraine

Back 1

> Neuronal discharges from upper brain stem and trigeminal system
> Lead to cerebral vasoconstriction (causing the headaches),
> which results in cortical spreading depression
> and changes in posterior cerebral cortical excitability (predisposing photopsias).

Front 2

Symptoms accompanying migraine

Back 2

1. Nausea
2. Vomiting
3. Visual Auras

Front 3

Phases of Migraine

Back 3

1. Prodrome phase
2. Aura phase
3. Headache (Pain) phase
4. Postdrome phase

Front 4

What happens during the aura and headache phase?

Back 4

Cerebral blood flow and metabolism are reduced and followed by hyperemia (increased bloodflow)
These phases are associated with mental confusion and difficulty thinking due to a temporary imbalance of cerebral neurotransmitters and serotoninergic systems.

Front 5

Which medicines help during a migraine attack? And what do they do?

Back 5

Injecting sumatriptan stimulates 5HT (serotonin) receptors) and receptors of blood vessels, which corrects the neuronal and cerebro-vascular transmitter disorder, with restoration of the neuronal 5HT function back to normal.

Front 6

Does depression influences psychometric testscores with vascular headaches?

Back 6

No.

Front 7

There are 4 different types of headache sufferers:

Back 7

1. Migraine with aura
2. Migraine without aura
3. Migraine converted to chronic daily headaches
4. Cluster headaches

Front 8

The "mini" test battery for patients with vascular headaches consists of?

Back 8

1. Mini Mental State Examination (MMSE)
2. Cognitive Capacity Status Examination (CCSE)
3. Hamilton Depression Rating Scales (HDRS)

All tests can be used headache present/absent

Front 9

Headache-related cognitive declines involves (7):

Back 9

1. Attention
2. Immediate Recall
3. Digit Retention
4. Arithmetic
5. Calculation
6. Acquisition of new words
7. Abstract Thinking
> Overall cognitive functioning

Front 10

Which variables were of influence on cognitive decline during vascular headaches?

Back 10

1. Age: CCSE scores declined more for younger subjects.
2. Gender: CCSE scores declined more for women.